Integrin signaling to the actin cytoskeleton Public Deposited

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Creator
  • Burridge, Keith
    • Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
  • Wennerberg, Krister
    • Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
  • DeMali, Kris A.
    • Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
Abstract
  • Integrin engagement stimulates the activity of numerous signaling molecules, including the Rho family of GTPases, tyrosine phosphatases, cAMP-dependent protein kinase and protein kinase C, and stimulates production of PtdIns(4,5)P2. Integrins promote actin assembly via the recruitment of molecules that directly activate the actin polymerization machinery or physically link it to sites of cell adhesion.
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Resource type
  • Journal Item
Rights statement
  • In Copyright
Journal title
  • Current Opinion in Cell Biology
Journal volume
  • 15
Journal issue
  • 5
Page start
  • 572
Page end
  • 582
Language
  • English
Version
  • Postprint
ISSN
  • 0955-0674
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