Interpretation of uniocular and binocular trials of glaucoma medications: an observational case series Public Deposited

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  • Amini, Lina
    • Affiliation: School of Medicine, Department of Ophthalmology
  • Leffler, Christopher T
    • Other Affiliation: Department of Ophthalmology, Virginia Commonwealth University, MCV Campus, MCV Box 980209, Richmond, VA 23298, USA
  • Abstract Background To predict the effectiveness of topical glaucoma medications based on initial uniocular and binocular treatment. To test a traditional hypothesis that effectiveness following a uniocular trial is associated with the change in IOP in the initially treated eye minus the change in the initially untreated eye. To determine whether uniocular or binocular treatment trials are superior. Methods Based on a review of medical records, we identified 168 instances in 154 patients with bilateral primary open angle glaucoma of initial uniocular use of a topical glaucoma medication with well-documented intraocular pressure (IOP) readings at baseline (IOPA), during the trial (IOPB), and at follow-up (IOPC). Abstracted data included demographic data, IOP, and medication use. Predictors of the IOP following the trial (IOPC) in each eye were identified by multivariable linear regression. In 70 cases, the predictive ability of initial uniocular and binocular treatment could be directly compared. Results In a multivariable analysis, the follow-up pressure in the initially treated eye (IOP1C) was directly correlated with treated eye IOP during initial uniocular use (IOP1B, p < 0.001). In a multivariable analysis, the follow-up pressure in the initially untreated eye (IOP2C) was directly correlated with its baseline IOP2A (p < 0.001), and also tended to be associated with treated IOP1B (p = 0.07). The multivariable regression coefficient (b) for the IOP change in the initially untreated eye was generally not close to the value of -1 expected by the classic teaching (for eye 1, b = 0.04, p = 0.35; for eye 2, b = 0.07, p = 0.50). In 70 cases, the uniocular and binocular trials predicted a similar fraction of the variance in follow-up IOP1C (r2 = 0.56 and 0.57, respectively) and IOP2C (r2 = 0.39 and 0.38, respectively). Conclusion 1) For uniocular trials, the IOP change in the untreated eye should not be subtracted from that in the treated eye. 2) Uniocular and binocular trials have similar predictive value when interpreted correctly. Either may be selected based on clinical circumstances.
Date of publication
  • doi:10.1186/1471-2415-7-17
  • 17916260
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • Christopher T Leffler et al.; licensee BioMed Central Ltd.
Journal title
  • BMC Ophthalmology
Journal volume
  • 7
Journal issue
  • 1
Page start
  • 17
  • English
Is the article or chapter peer-reviewed?
  • Yes
  • 1471-2415
Bibliographic citation
  • BMC Ophthalmology. 2007 Oct 05;7(1):17
  • Open Access
  • BioMed Central Ltd

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