Association of PTSD With Longitudinal COVID-19 Burden in a Mixed-Serostatus Cohort of Men and Women: Weathering the Storm

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  • Jones, D.L.
    • Other Affiliation: University of Miami Miller School of Medicine
  • Zhang, Y.
    • Other Affiliation: Johns Hopkins Bloomberg School of Public Health
  • Rodriguez, V.J.
    • Other Affiliation: University of Georgia
  • Haberlen, S.
    • Other Affiliation: Johns Hopkins School of Public Health
  • Ramirez, C.
    • Affiliation: School of Medicine, Department of Medicine
  • Adimora, A.A.
    • Affiliation: School of Medicine, Department of Medicine
  • Merenstein, D.
    • Other Affiliation: Georgetown University Medical Center
  • Aouizerat, B.
    • Other Affiliation: New York University
  • Sharma, A.
    • Other Affiliation: Albert Einstein College of Medicine
  • Wilson, T.
    • Other Affiliation: State University of New York-Downstate Health Sciences University
  • Mimiaga, M.J.
    • Other Affiliation: University of California, Los Angeles
  • Sheth, A.N.
    • Other Affiliation: Emory University
  • Plankey, M.
    • Other Affiliation: Georgetown University Medical Center
  • Cohen, M.H.
    • Other Affiliation: Stroger Hospital of Cook County
  • Stosor, V.
    • Other Affiliation: Northwestern University
  • Kempf, M.-C.
    • Other Affiliation: University of Alabama at Birmingham
  • Friedman, M.R.
    • Other Affiliation: University of Pittsburgh
Abstract
  • Objectives:This study of people with HIV (PWH) and those without HIV conducted during the COVID-19 pandemic in the United States in 2020 examines the impact of posttraumatic stress disorder (PTSD) on COVID-19 burden, defined as pandemic-related disruptions.Methods:Data consisted of survey responses on PTSD among participants (N = 2434) enrolled in the Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV (WIHS) cohorts. Unadjusted and adjusted regression models were used to examine the association of PTSD with COVID-19 burden (overall and domain-specific burdens). Quasi-Poisson regression models were used to assess associations with the COVID-19 burden score and 2 domain-specific burdens: (1) changes in resources and (2) interruptions in health care. Analyses was adjusted for age, race/ethnicity, HIV serostatus, current smoking status, number of comorbidities, education, and study regions.Results:Study participants were a median age of 58 (interquartile range, 52-65) years. In both bivariate and multivariable models, PTSD severity was associated with greater overall COVID-19 burden. PTSD severity was associated with the number of resource changes and number of interruptions in medical care. These findings were also consistent across cohorts (MACS/WIHS) and across HIV serostatus, suggesting a greater risk for COVID-19 burden with greater PTSD severity, which remained significant after controlling for covariates.Conclusions:This study builds on emerging literature demonstrating the impact of mental health on the burden and disruption associated with the COVID-19 pandemic, providing context specific to PWH. The ongoing pandemic requires structural and social interventions to decrease disruption to resources and health resource needs among these vulnerable populations.
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Resource type
  • Article
Journal title
  • Journal of Acquired Immune Deficiency Syndromes
Journal volume
  • 90
Journal issue
  • 5
Page end
  • 575
Language
  • English
Version
  • Postprint
Funder
  • Office of AIDS Research, OAR: UL1-TR000004
  • Philanthropic Educational Organization, P.E.O.: R36MH127838
  • National Institute of Allergy and Infectious Diseases, NIAID
  • Clinical and Translational Science Institute, University of California, Los Angeles, UCLA CTSI: P30-AI-050409
  • Miami Center for AIDS Research, CFAR: P30-AI-050410
  • Center for AIDS Research, University of Alabama at Birmingham, CFAR: P30-MH-116867
  • P30-AI-073961
  • National Institute of Neurological Disorders and Stroke, NINDS
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD
  • National Institute of Dental and Craniofacial Research, NIDCR
  • National Institute on Alcohol Abuse and Alcoholism, NIAAA
  • National Institutes of Health, NIH
  • Ford Foundation, FF
  • National Institute on Deafness and Other Communication Disorders, NIDCD
  • Center for AIDS Research, University of North Carolina at Chapel Hill, UNC CFAR: P30-AI-027767
  • National Institute of Diabetes and Digestive and Kidney Diseases, NIDDK
  • National Cancer Institute, NCI
  • National Institute on Drug Abuse, NIDA
  • University of California, San Francisco, UCSF: UL1-TR001881, UL1-TR003098
  • National Institute of Nursing Research, NINR
  • National Institute on Minority Health and Health Disparities, NIMHD
  • National Institute of Mental Health, NIMH
  • National Heart, Lung, and Blood Institute, NHLBI
  • National Institute on Aging, NIA
ISSN
  • 1525-4135
Publisher
  • Lippincott Williams and Wilkins

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