Estimating the cost-effectiveness of nutrition supplementation for malnourished, HIV-infected adults starting antiretroviral therapy in a resource-constrained setting Public Deposited

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Creator
  • Marseille, Elliot
    • Other Affiliation: Health Strategies International, 555 59th Street, Oakland, CA 94609, USA
  • Koethe, John R
    • Other Affiliation: Centre for Infectious Diseases Research in Zambia, Plot 5032 Great North Road, Lusaka, Zambia; Division of Infectious Diseases, Vanderbilt University School of Medicine, 215 Light Hall, Nashville, TN 37232, USA
  • Chi, Benjamin
    • Affiliation: School of Medicine, Department of Obstetrics and Gynecology
    • Other Affiliation: Centre for Infectious Diseases Research in Zambia, Plot 5032 Great North Road, Lusaka, Zambia
  • Giganti, Mark J
    • Other Affiliation: Centre for Infectious Diseases Research in Zambia, Plot 5032 Great North Road, Lusaka, Zambia; Department of Biostatistics, Vanderbilt University School of Medicine, 215 Light Hall, Nashville, TN 37232, USA
  • Stringer, Jeffrey
    • Affiliation: School of Medicine, Department of Obstetrics and Gynecology
    • Other Affiliation: Centre for Infectious Diseases Research in Zambia, Plot 5032 Great North Road, Lusaka, Zambia
  • Heimburger, Douglas
    • Other Affiliation: Centre for Infectious Diseases Research in Zambia, Plot 5032 Great North Road, Lusaka, Zambia; Vanderbilt Institute for Global Health, 2525 West End Ave., Nashville, TN 37203, USA
Abstract
  • Abstract Background Low body mass index (BMI) individuals starting antiretroviral therapy (ART) for HIV infection in sub-Saharan Africa have high rates of death and loss to follow-up in the first 6 months of treatment. Nutritional supplementation may improve health outcomes in this population, but the anticipated benefit of any intervention should be commensurate with the cost given resource limitations and the need to expand access to ART in the region. Methods We used Markov models incorporating historical data and program-wide estimates of treatment costs and health benefits from the Zambian national ART program to estimate the improvements in 6-month survival and program retention among malnourished adults necessary for a combined nutrition support and ART treatment program to maintain cost-effectiveness parity with ART treatment alone. Patients were stratified according to World Health Organization criteria for severe (BMI <16.0 kg/m2), moderate (16.00-16.99 kg/m2), and mild (17.00-18.49 kg/m2) malnutrition categories. Results 19,247 patients contributed data between May 2004 and October 2010. Quarterly survival and retention were lowest in the BMI <16.0 kg/m2 category compared to higher BMI levels, and there was less variation in both measures across BMI strata after 180 days. ART treatment was estimated to cost $556 per year and averted 7.3 disability-adjusted life years. To maintain cost-effectiveness parity with ART alone, a supplement needed to cost $10.99 per quarter and confer a 20% reduction in both 6-month mortality and loss to follow-up among BMI <16.0 kg/m2 patients. Among BMI 17.00-18.49 kg/m2 patients, supplement costs accompanying a 20% reduction in mortality and loss to follow-up could not exceed $5.18 per quarter. In sensitivity analyses, the maximum permitted supplement cost increased if the ART program cost rose, and fell if patients classified as lost to follow-up at 6 months subsequently returned to care. Conclusions Low BMI adults starting ART in sub-Saharan Africa are at high risk of early mortality and loss to follow-up. The expense of providing nutrition supplementation would require only modest improvements in survival and program retention to be cost-effective for the most severely malnourished individuals starting ART, but interventions are unlikely to be cost-effective among those in higher BMI strata.
Date of publication
Identifier
  • doi:10.1186/1478-7547-12-10
  • 24839400
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • John R Koethe et al.; licensee BioMed Central Ltd.
License
Journal title
  • Cost Effectiveness and Resource Allocation
Journal volume
  • 12
Journal issue
  • 1
Page start
  • 10
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1478-7547
Bibliographic citation
  • Cost Effectiveness and Resource Allocation. 2014 Apr 27;12(1):10
Access
  • Open Access
Publisher
  • BioMed Central Ltd
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