Circulating short-chain fatty acids are positively associated with adiposity measures in chinese adults

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  • Wang, Y.
    • Gillings School of Global Public Health, Department of Nutrition
  • Wang, H.
    • Other Affiliation: Chinese Center for Disease Control and Prevention
  • Howard, A.G.
    • Gillings School of Global Public Health, Department of Biostatistics
  • Meyer, K.A.
    • Gillings School of Global Public Health, Department of Nutrition
  • Tsilimigras, M.C.B.
    • Gillings School of Global Public Health, Department of Nutrition
  • Avery, C.L.
    • Gillings School of Global Public Health, Department of Epidemiology
  • Sha, W.
    • Other Affiliation: University of North Carolina at Charlotte
  • Sun, S.
    • Other Affiliation: University of North Carolina at Charlotte
  • Zhang, J.
    • Other Affiliation: Chinese Center for Disease Control and Prevention
  • Su, C.
    • Other Affiliation: Chinese Center for Disease Control and Prevention
  • Wang, Z.
    • Other Affiliation: Chinese Center for Disease Control and Prevention
  • Zhang, B.
    • Other Affiliation: Chinese Center for Disease Control and Prevention
  • Fodor, A.A.
    • Other Affiliation: University of North Carolina at Charlotte
  • Gordon-Larsen, P.
    • Gillings School of Global Public Health, Department of Nutrition
Abstract
  • Epidemiological studies suggest a positive association between obesity and fecal short-chain fatty acids (SCFAs) produced by microbial fermentation of dietary carbohydrates, while animal models suggest increased energy harvest through colonic SCFA production in obesity. However, there is a lack of human population-based studies with dietary intake data, plasma SCFAs, gut microbial, and anthropometric data. In 490 Chinese adults aged 30–68 years, we examined the associations between key plasma SCFAs (butyrate/isobutyrate, isovalerate, and valerate measured by non-targeted plasma metabolomics) with body mass index (BMI) using multivariable-adjusted linear regression. We then assessed whether overweight (BMI ≥ 24 kg/m2 ) modified the association between dietary-precursors of SCFAs (insoluble fiber, total carbohydrates, and high-fiber foods) with plasma SCFAs. In a sub-sample (n = 209) with gut metagenome data, we examined the association between gut microbial SCFA-producers with BMI. We found positive associations between butyrate/isobutyrate and BMI (p-value < 0.05). The associations between insoluble fiber and butyrate/isobutyrate differed by overweight (p-value < 0.10). There was no statistical evidence for an association between microbial SCFA-producers and BMI. In sum, plasma SCFAs were positively associated with BMI and that the colonic fermentation of fiber may differ for adults with versus without overweight.
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  • Article
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  • In Copyright
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  • Attribution 4.0 International
Journal title
  • Nutrients
Journal volume
  • 12
Journal issue
  • 7
Page start
  • 1
Page end
  • 15
Language
  • English
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  • Publisher
ISSN
  • 2072-6643
Publisher
  • MDPI AG

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