Molecular insights into psychedelic drug action

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Creator
  • Slocum S.T
    • School of Medicine, Department of Pharmacology
  • DiBerto J.F
    • School of Medicine, Department of Pharmacology
  • Roth B.L
    • School of Medicine, Department of Pharmacology
Abstract
  • A confluence of factors has renewed interest in the scientific understanding and translational potential of psychedelic drugs such as lysergic acid diethylamide (LSD), mescaline, and psilocybin: the desire for additional approaches to mental health care, incremental progress in basic and clinical research, and the reconsideration and relaxation of existing drug policies. With the United States Food and Drug Administration's designation of psilocybin as a “Breakthrough Therapy” for treatment-resistant depression, a new path has been forged for the conveyance of psychedelics to the clinic. Essential to the further development of such applications, however, is a clearer understanding of how these drugs exert their effects at the molecular level. Here we review the current knowledge regarding the molecular details of psychedelic drug actions and suggest that these discoveries can facilitate new insights into their hallucinogenic and therapeutic mechanisms.
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Resource type
  • Article
Rights statement
  • In Copyright
Journal title
  • Journal of Neurochemistry
Journal volume
  • 162
Journal issue
  • 1
Page start
  • 24
Page end
  • 38
Language
  • English
Funder
  • National Institute on Drug Abuse, NIDA, (R37DA045657)
ISSN
  • 0022-3042
Publisher
  • John Wiley and Sons Inc

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