Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression Public Deposited

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Creator
  • Parker, Joel
    • Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, School of Medicine
  • Karaca, Gamze
    • Affiliation: School of Medicine, Department of Genetics, N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
  • Shockley, William W.
    • Affiliation: School of Medicine, Department of Otolaryngology/Head and Neck Surgery
  • Shores, Carol G
    • Affiliation: School of Medicine, Department of Otolaryngology/Head and Neck Surgery
  • Funkhouser, William
    • Affiliation: School of Medicine, Department of Pathology and Laboratory Medicine, N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
  • Perou, Charles
    • ORCID: https://orcid.org/0000-0001-9827-2247
    • Affiliation: School of Medicine, Department of Genetics, Department of Pathology and Laboratory Medicine, N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
  • Moore, Dominic T.
    • Affiliation: Gillings School of Global Public Health, Department of Biostatistics, N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, School of Medicine
  • Butterfoss, Dale
    • Affiliation: School of Medicine, Department of Genetics, N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
  • Yin, Xiaoying
    • Affiliation: School of Medicine, Department of Otolaryngology/Head and Neck Surgery
  • Chung, Christine H.
    • Other Affiliation: Division of Hematology/Oncology, Department of Medicine, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 2220 Pierce Avenue, 777 Preston Research Building, Nashville, Tennessee 37232
  • Yarbrough, Wendell G.
    • Other Affiliation: Vanderbilt-Ingram Cancer Center, Department of Cancer Biology, Vanderbilt University, S-2100 Medical Center North, Nashville, Tennessee 37232
  • Wu, Junyuan
    • Affiliation: School of Medicine, Department of Genetics, N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
  • Xiang, Dong
    • Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, School of Medicine
  • Dressler, Lynn
    • Affiliation: School of Medicine, Department of Medicine
  • Weissler, Mark C.
    • Affiliation: School of Medicine, Department of Otolaryngology/Head and Neck Surgery
  • Zanation, Adam
    • Affiliation: School of Medicine, Department of Otolaryngology/Head and Neck Surgery
Abstract
  • The prognostication of head and neck squamous cell carcinoma (HNSCC) is largely based upon the tumor size and location and the presence of lymph node metastases. Here we show that gene expression patterns from 60 HNSCC samples assayed on cDNA microarrays allowed categorization of these tumors into four distinct subtypes. These subtypes showed statistically significant differences in recurrence-free survival and included a subtype with a possible EGFR-pathway signature, a mesenchymal-enriched subtype, a normal epithelium-like subtype, and a subtype with high levels of antioxidant enzymes. Supervised analyses to predict lymph node metastasis status were approximately 80% accurate when tumor subsite and pathological node status were considered simultaneously. This work represents an important step toward the identification of clinically significant biomarkers for HNSCC.
Date of publication
Identifier
  • 2-s2.0-2342492313
  • doi:10.1016/S1535-6108(04)00112-6
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Resource type
  • Article
Rights statement
  • In Copyright
Journal title
  • Cancer Cell
Journal volume
  • 5
Journal issue
  • 5
Page start
  • 489
Page end
  • 500
Language
  • English
Version
  • Postprint
ISSN
  • 1535-6108
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