A 19-year-old man with sickle cell disease presenting with spinal infarction: a case report Public Deposited

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  • Clay, E. Leila Jerome
    • Affiliation: School of Medicine, Department of Pediatrics, Division of Hematology/Oncology, Department of Medicine
    • Other Affiliation: Departments of Pediatrics and Internal Medicine, Division of Hematology and Oncology, Georgia Regents University, 1120 15th Street, BH 2015, Augusta, GA 30912, USA
  • Jewells, Valerie
    • Affiliation: School of Medicine, Department of Radiology
  • Redding-Lallinger, Rupa
    • Affiliation: School of Medicine, Department of Pediatrics, Division of Hematology/Oncology, Department of Medicine
  • Edwards, April
    • Affiliation: School of Medicine, Department of Pediatrics
  • Adams, Stacie
    • Other Affiliation: Department of Pediatrics, Michigan State University, GRMEP 1000 Monroe Avenue, NW, Grand Rapids, MI 49503, USA
  • Crawford, Regina D.
    • Other Affiliation: Department of Medicine, Division of Hematology, Duke University Medical Center, 2212 Elba Street DUMC Box 3939, Durham, NC 27705, USA
  • Abstract Introduction Vasculopathy of the large vessels commonly occurs in sickle cell disease, and as a result cerebral infarction is a well characterized complication of this condition. However, spinal infarction appears to be rare. Spinal infarct is infrequent in the non-sickle cell population as well, and accounts for only about 1 percent of all central nervous system infarcts. Case presentation In the present work, we report the case of a 19-year-old African-American man with sickle cell disease who experienced an anterior spinal infarct and subsequent quadriplegia. He was incidentally noted to be a heterozygote for factor V Leiden. We also reviewed the literature and found two previous cases of spinal cord infarction and sickle hemoglobin. Our literature search did not demonstrate that heterozygocity for factor V Leiden plays an important role in spinal cord infarction. Conclusions The paucity of cases associated with sickle hemoglobin does not allow us to postulate any particular risk factors with sickle cell disease that might predispose patients to spinal cord infarction. Our patient’s case raises the question as to whether spinal cord infarction is being missed in individuals with sickle cell disease and neurologic symptoms.
Date of publication
  • doi:10.1186/1752-1947-7-210
  • 23972124
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • April Edwards et al.; licensee BioMed Central Ltd.
Journal title
  • Journal of Medical Case Reports
Journal volume
  • 7
Journal issue
  • 1
Page start
  • 210
  • English
Is the article or chapter peer-reviewed?
  • Yes
  • 1752-1947
Bibliographic citation
  • Journal of Medical Case Reports. 2013 Aug 23;7(1):210
  • Open Access
  • BioMed Central Ltd

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