Creator

• Francis, S. M.
  • Other Affiliation: University of Minnesota Twin Cities
• Sagar, A.
  • Other Affiliation: University of California, Irvine
• Levin-Decanini, T.
  • Other Affiliation: University of Minnesota Twin Cities
• Liu, W.
  • Other Affiliation: Northwestern University Feinberg School of Medicine
• Carter, C. S.
  • Affiliation: University of North Carolina at Chapel Hill
• Jacob, S.
  • Other Affiliation: University of Minnesota Twin Cities

Abstract

• Oxytocin (OT) and arginine vasopressin (AVP) are two small, related neuropeptide hormones found in many mammalian species, including humans. Dysregulation of these neuropeptides have been associated with changes in behavior, especially social interactions. We review how the OT and AVP systems have been investigated in Autism Spectrum Disorder (ASD), Prader–Willi Syndrome (PWS), Williams Syndrome (WS) and Fragile X syndrome (FXS). All of these neurodevelopmental disorders (NDD) are marked by social deficits. While PWS, WS and FXS have identified genetic mutations, ASD stems from multiple genes with complex interactions. Animal models of NDD are invaluable for studying the role and relatedness of OT and AVP in the developing brain. We present data from a FXS mouse model affecting the fragile X mental retardation 1 (Fmr1) gene, resulting in decreased OT and AVP staining cells in some brain regions. Reviewing the research about OT and AVP in these NDD suggests that altered OT pathways may be downstream from different etiological factors and perturbations in development. This has implications for ongoing studies of the therapeutic application of OT in NDD.

Date of publication

• 2014

Keyword

• Fragile X
• Vasopressins
• Humans
• Prader–Willi
• Vasopressin
• Prader-Willi Syndrome
• Williams Syndrome
• Brain
• Oxytocin
• Autism
• Fragile X Syndrome
• Animals
• Child Development Disorders, Pervasive
• Williams
• Psychotropic Drugs

DOI

• https://doi.org/10.17615/zm7q-z293

Identifier

• PMCID: PMC4305432
• PMID: 24462936
• Publisher DOI: https://doi.org/10.1016/j.brainres.2014.01.021
• Onescience id: 7acd1d84d5c6f8ca817f1ec36bffe0270940d0cd

Resource type

• Article

Rights statement

• In Copyright

Journal title

• Brain Research

Journal volume

• 1580

Page start

• 199

Page end

• 218

Language

• English

ISSN

• 1872-6240
• 0006-8993
• 0921-8246

Parents:

This work has no parents.

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