Nanoparticle delivery enhancement with acoustically activated microbubbles Public Deposited
- Creator
- Mullin, L. B.
- Phillips, L. C.
- Dayton, P. A.
- Abstract
- The application of microbubbles and ultrasound to deliver nanoparticle carriers for drug and gene delivery is an area that has expanded greatly in recent years. Under ultrasound exposure, microbubbles can enhance nanoparticle delivery by increasing cellular and vascular permeability. In this review, the underlying mechanisms of enhanced nanoparticle delivery with ultrasound and microbubbles and various proposed delivery techniques are discussed. Additionally, types of nanoparticles currently being investigated in preclinical studies, as well as the general limitations and benefits of a microbubble-based approach to nanoparticle delivery are reviewed.
- Date of publication
- 2013
- Keyword
- gene therapy
- Ultrasonic imaging
- acoustically activated microbubbles
- permeability
- gene delivery
- microbubble-based approach
- Drugs
- nanoparticle carriers
- vascular permeability
- Nanoparticles
- drug delivery
- Permeability
- nanoparticles
- cellular permeability
- cellular biophysics
- Plastics
- Animals
- Tumors
- biomedical ultrasonics
- nanoparticle delivery enhancement
- nanomedicine
- Acoustics
- drug delivery systems
- ultrasound application
- bubbles
- DOI
- Identifier
- PMCID: PMC3822910
- Onescience id: 2009b430aad09a69c6b63571ce44ca6ff6fe64ba
- PMID: 23287914
- Publisher DOI: https://doi.org/10.1109/TUFFC.2013.2538
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
- Journal volume
- 60
- Journal issue
- 1
- Language
- English
- ISSN
- 2373-7840
- 1525-8955
- 0885-3010
- Parents:
This work has no parents.
Items
| Thumbnail | Title | Date Uploaded | Visibility | Actions |
|---|---|---|---|---|
|
|
EuropePMC-PMC3822910.pdf | 2020-10-30 | Public |
|