Modulation of the high-order chromatin structure by Polycomb complexes

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  • Guo, Y.
    • Affiliation: School of Medicine, Department of Biochemistry and Biophysics
  • Wang, G.G.
    • Affiliation: School of Medicine, Department of Biochemistry and Biophysics
Abstract
  • The multi-subunit Polycomb Repressive Complex (PRC) 1 and 2 act, either independently or synergistically, to maintain and enforce a repressive state of the target chromatin, thereby regulating the processes of cell lineage specification and organismal development. In recent years, deep sequencing-based and imaging-based technologies, especially those tailored for mapping three-dimensional (3D) chromatin organization and structure, have allowed a better understanding of the PRC complex-mediated long-range chromatin contacts and DNA looping. In this review, we review current advances as for how Polycomb complexes function to modulate and help define the high-order chromatin structure and topology, highlighting the multi-faceted roles of Polycomb proteins in gene and genome regulation.
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  • Article
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  • Attribution 4.0 International
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  • Frontiers in Cell and Developmental Biology
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  • 10
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  • English
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  • National Institutes of Health, NIH: R01-CA215284, R01-CA218600
  • American Cancer Society, ACS; Leukemia and Lymphoma Society, LLS

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