Lactobacillus GG in inducing and maintaining remission of Crohn's disease Public Deposited

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Creator
  • Vanderhoof, Jon A
    • Other Affiliation: University of Nebraska at Omaha, School of Medicine, Department of Pediatrics, Omaha, NE, USA
  • Rath, Heiko C
    • Other Affiliation: Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
  • Timmer, Antje
    • Other Affiliation: Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
  • Sartor, Balfour
    • Affiliation: School of Medicine, Department of Medicine, Division of Gastroenterology and Hepatology
  • Herfarth, Hans H
    • Other Affiliation: Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
  • Schultz, Michael
    • Other Affiliation: Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
Abstract
  • Abstract Background Experimental studies have shown that luminal antigens are involved in chronic intestinal inflammatory disorders such as Crohn's disease and ulcerative colitis. Alteration of the intestinal microflora by antibiotic or probiotic therapy may induce and maintain remission. The aim of this randomized, placebo-controlled trial was to determine the effect of oral Lactobacillus GG (L. GG) to induce or maintain medically induced remission. Methods Eleven patients with moderate to active Crohn's disease were enrolled in this trial to receive either L. GG (2 × 109 CFU/day) or placebo for six months. All patients were started on a tapering steroid regime and received antibiotics for the week before the probiotic/placebo medication was initiated. The primary end point was sustained remission, defined as freedom from relapse at the 6 months follow-up visit. Relapse was defined as an increase in CDAI of >100 points. Results 5/11 patients finished the study, with 2 patients in each group in sustained remission. The median time to relapse was 16 ± 4 weeks in the L. GG group and 12 ± 4.3 weeks in the placebo group (p = 0.5). Conclusion In this study we could not demonstrate a benefit of L. GG in inducing or maintaining medically induced remission in CD.
Date of publication
Identifier
  • doi:10.1186/1471-230X-4-5
  • 15113451
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • Michael Schultz et al.; licensee BioMed Central Ltd.
Journal title
  • BMC Gastroenterology
Journal volume
  • 4
Journal issue
  • 1
Page start
  • 5
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1471-230X
Bibliographic citation
  • BMC Gastroenterology. 2004 Mar 15;4(1):5
Access
  • Open Access
Publisher
  • BioMed Central Ltd
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