Targeting Membrane Trafficking as a Strategy for Cancer Treatment

Public Deposited
Analytics

Downloadable Content

Download PDF
Request Version for Screen Reader
Creator
  • Tejeda-Muñoz, Nydia
    • Other Affiliation: University of California, Los Angeles
  • Mei, Kuo-Ching
    • Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular Pharmaceutics
  • Sheladiya, Pooja
    • Other Affiliation: University of California, Los Angeles
  • Monka, Julia
    • Other Affiliation: University of California, Los Angeles
Abstract
  • Membrane trafficking is emerging as an attractive therapeutic strategy for cancer. Recent reports have found a connection between Wnt signaling, receptor-mediated endocytosis, V-ATPase, lysosomal activity, and macropinocytosis through the canonical Wnt pathway. In macropinocytic cells, a massive internalization of the plasma membrane can lead to the loss of cell-surface cadherins, integrins, and other antigens that mediate cell–cell adhesion, favoring an invasive phenotype. V-ATPase is a key regulator in maintaining proper membrane trafficking, homeostasis, and the earliest developmental decisions in the Xenopus vertebrate development model system. Here, we review how the interference of membrane trafficking with membrane trafficking inhibitors might be clinically relevant in humans.
Date of publication
Keyword
DOI
Identifier
Resource type
  • Article
Rights statement
  • In Copyright
License
  • Attribution 4.0 International
Journal title
  • Vaccines
Journal volume
  • 10
Journal issue
  • 5
Page start
  • 790
Language
  • English
Version
  • Publisher
ISSN
  • 2076-393X

Relations

Parents:

This work has no parents.

In Collection:

Items

Thumbnail Title Date Uploaded Visibility Actions
file details vaccines-10-00790.pdf 2022-06-02 Public Download