Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa Public Deposited

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  • Vidal, Adriana C
    • Other Affiliation: Department of Obstetrics and Gynecology, and Program of Cancer Detection, Prevention and Control, for Duke University School of Medicine, Durham, North Carolina
  • Lund, Pauline Kay
    • Affiliation: Center for Gastrointestinal Biology and Disease, School of Medicine, Department of Medicine, Department of Cell Biology and Physiology
  • Keku, Temitope
    • Affiliation: Center for Gastrointestinal Biology and Disease, School of Medicine, Department of Medicine
  • Holston, Rachel
    • Affiliation: Center for Gastrointestinal Biology and Disease, School of Medicine, Department of Medicine
  • Hoyo, Cathrine
    • Other Affiliation: Department of Obstetrics and Gynecology, and Program of Cancer Detection, Prevention and Control, for Duke University School of Medicine, Durham, North Carolina
  • Galanko, Joseph
    • Affiliation: Center for Gastrointestinal Biology and Disease, School of Medicine, Department of Medicine
  • Omofoye, Oluwaseun
    • Affiliation: Center for Gastrointestinal Biology and Disease, School of Medicine, Department of Medicine
  • Massa, Berri
    • Affiliation: Center for Gastrointestinal Biology and Disease, School of Medicine, Department of Medicine
  • Sandler, Robert
    • Affiliation: Center for Gastrointestinal Biology and Disease, School of Medicine, Department of Medicine
  • Burcal, Lauren
    • Affiliation: Center for Gastrointestinal Biology and Disease, School of Medicine, Department of Medicine
Abstract
  • Abstract Background Lower concentrations of the insulin–like growth factor binding protein-1 (IGFBP-1) and elevated concentrations of insulin or C-peptide have been associated with an increase in colorectal cancer risk (CRC). However few studies have evaluated IGFBP-1 and C-peptide in relation to adenomatous polyps, the only known precursor for CRC. Methods Between November 2001 and December 2002, we examined associations between circulating concentrations of insulin, C-peptide, IGFBP-1 and apoptosis among 190 individuals with one or more adenomatous polyps and 488 with no adenomatous polyps using logistic regression models. Results Individuals with the highest concentrations of C-peptide were more likely to have adenomas (OR = 2.2, 95% CI 1.4-4.0) than those with the lowest concentrations; associations that appeared to be stronger in men (OR = 4.4, 95% CI 1.7-10.9) than women. Individuals with high insulin concentrations also had a higher risk of adenomas (OR = 3.5, 95% CI 1.7-7.4), whereas higher levels of IGFBP-1 were associated with a reduced risk of adenomas in men only (OR = 0.3, 95% CI 0.1-0.7). Overweight and obese individuals with higher C-peptide levels (>1st Q) were at increased risk for lower apoptosis index (OR = 2.5, 95% CI 0.9-7.1), an association that remained strong in overweight and obese men (OR = 6.3, 95% CI 1.0-36.7). Higher levels of IGFBP-1 in overweight and obese individuals were associated with a reduced risk of low apoptosis (OR = 0.3, 95% CI 0.1-1.0). Conclusions Associations between these peptides and the apoptosis index in overweight and obese individuals, suggest that the mechanism by which C-peptide could induce adenomas may include its anti-apoptotic properties. This study suggests that hyperinsulinemia and IGF hormones predict adenoma risk, and that outcomes associated with colorectal carcinogenesis maybe modified by gender.
Date of publication
Identifier
  • doi:10.1186/1471-2407-12-389
  • 22950808
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • Adriana C Vidal et al.; licensee BioMed Central Ltd.
License
Journal title
  • BMC Cancer
Journal volume
  • 12
Journal issue
  • 1
Page start
  • 389
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1471-2407
Bibliographic citation
  • BMC Cancer. 2012 Sep 05;12(1):389
Access
  • Open Access
Publisher
  • BioMed Central Ltd
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