The Viral Interferon Regulatory Factors of KSHV: Immunosuppressors or Oncogenes?
Public Deposited- Creator
- Jacobs, Sarah R.
- Damania, Blossom
- Abstract
- Kaposi’s sarcoma-associated herpesvirus (KSHV) is a large double-stranded DNA gammaherpesvirus, and the etiological agent for three human malignancies: Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. To establish and maintain infection, KSHV has evolved unique mechanisms to evade the host immune response. Cellular interferon regulatory factors (IRFs) are a critical part of the host anti-viral immune response. KSHV encodes four homologs of IRFs, vIRF1–4, which inhibit the activity of their cellular counterparts. vIRF1, 2, and 3 have been shown to interact directly with cellular IRFs. Additionally, the vIRFs have other functions such as modulation of Myc, p53, Notch, transforming growth factor-β, and NF-κB signaling. These activities of vIRFs may contribute to KSHV tumorigenesis. KSHV vIRF1 and vIRF3 have been implicated as oncogenes, making the understanding of KSHV vIRF function vital to understanding KSHV pathogenesis.
- Date of publication
- 2011
- Keyword
- DOI
- Identifier
- Onescience id: e79a83a7bcf91572f444687876d28454b78c2e47
- Publisher DOI: https://doi.org/10.3389/fimmu.2011.00019
- PMCID: PMC3342017
- PMID: 22566809
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Frontiers in Immunology
- Journal volume
- 2
- Language
- English
- ISSN
- 1664-3224
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