Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2

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  • Walls, A.C.
    • Other Affiliation: University of Washington
  • Fiala, B.
    • Other Affiliation: University of Washington
  • Schäfer, A.
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Wrenn, S.
    • Other Affiliation: University of Washington
  • Pham, M.N.
    • Other Affiliation: University of Washington
  • Murphy, M.
    • Other Affiliation: University of Washington
  • Tse, L.V.
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Shehata, L.
    • Other Affiliation: University of Washington
  • O'Connor, M.A.
    • Other Affiliation: University of Washington
  • Chen, C.
    • Other Affiliation: University of Washington
  • Navarro, M.J.
    • Other Affiliation: University of Washington
  • Miranda, M.C.
    • Other Affiliation: University of Washington
  • Pettie, D.
    • Other Affiliation: University of Washington
  • Ravichandran, R.
    • Other Affiliation: University of Washington
  • Kraft, J.C.
    • Other Affiliation: University of Washington
  • Ogohara, C.
    • Other Affiliation: University of Washington
  • Palser, A.
    • Other Affiliation: Kymab Ltd.
  • Chalk, S.
    • Other Affiliation: Kymab Ltd.
  • Lee, E.-C.
    • Other Affiliation: Kymab Ltd.
  • Guerriero, K.
    • Other Affiliation: University of Washington
  • Kepl, E.
    • Other Affiliation: University of Washington
  • Chow, C.M.
    • Other Affiliation: University of Washington
  • Sydeman, C.
    • Other Affiliation: University of Washington
  • Hodge, E.A.
    • Other Affiliation: University of Washington
  • Brown, B.
    • Other Affiliation: University of Washington
  • Fuller, J.T.
    • Other Affiliation: University of Washington
  • Dinnon, III, K.H.
    • Affiliation: School of Medicine, Department of Microbiology and Immunology
  • Gralinski, L.E.
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Leist, S.R.
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Gully, K.L.
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Lewis, T.B.
    • Other Affiliation: University of Washington
  • Guttman, M.
    • Other Affiliation: University of Washington
  • Chu, H.Y.
    • Other Affiliation: University of Washington
  • Lee, K.K.
    • Other Affiliation: University of Washington
  • Fuller, D.H.
    • Other Affiliation: University of Washington
  • Baric, R.S.
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Kellam, P.
    • Other Affiliation: Kymab Ltd.
  • Carter, L.
    • Other Affiliation: University of Washington
  • Pepper, M.
    • Other Affiliation: University of Washington
  • Sheahan, T.P.
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Veesler, D.
    • Other Affiliation: University of Washington
  • King, N.P.
    • Other Affiliation: University of Washington
Abstract
  • Walls et al. describe a potential nanoparticle vaccine for COVID-19, made of a self-assembling protein nanoparticle displaying the SARS-CoV-2 receptor-binding domain in a highly immunogenic array reminiscent of the natural virus. Their nanoparticle vaccine candidate elicits a diverse, potent, and protective antibody response, including neutralizing antibody titers 10-fold higher than the prefusion-stabilized spike ectodomain trimer.
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  • Article
Rights statement
  • In Copyright
License
  • Attribution 3.0 United States
Journal title
  • Cell
Journal volume
  • 183
Journal issue
  • 5
Page start
  • 1367
Page end
  • 1.38E+20
Language
  • English
Version
  • Publisher
ISSN
  • 0092-8674
Publisher
  • Cell Press

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