Association between general joint hypermobility and knee, hip, and lumbar spine osteoarthritis by race: a cross-sectional study Public Deposited

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  • Nelson, Amanda E
    • Affiliation: School of Medicine, Thurston Arthritis Research Center, Department of Medicine, Division of Rheumatology, Allergy and Immunology
  • Cleveland, Rebecca J
    • Affiliation: School of Medicine, Thurston Arthritis Research Center, Department of Medicine, Division of Rheumatology, Allergy and Immunology
  • Hillstrom, Howard J
    • Other Affiliation: Motion Analysis Laboratory, Hospital for Special Surgery, New York, USA
  • Renner, Jordan B
    • Affiliation: School of Medicine, Department of Radiology, Thurston Arthritis Research Center, Department of Medicine, Division of Rheumatology, Allergy and Immunology
  • Golightly, Yvonne
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology, School of Medicine, Thurston Arthritis Research Center, Injury Prevention Research Center, Department of Medicine, Division of Rheumatology, Allergy and Immunology
  • Flowers, Portia P E
    • Affiliation: School of Medicine, Thurston Arthritis Research Center, Department of Medicine, Division of Rheumatology, Allergy and Immunology
  • Schwartz, Todd
    • Affiliation: Gillings School of Global Public Health, Department of Biostatistics, School of Nursing, School of Medicine, Thurston Arthritis Research Center, Department of Medicine, Division of Rheumatology, Allergy and Immunology
  • Hannan, Marian T
    • Other Affiliation: Institute for Aging Research, Hebrew SeniorLife, Boston, USA
  • Goode, Adam P
    • Other Affiliation: Department of Orthopedic Surgery, Duke Clinical Research Institute, School of Medicine, Duke University, Durham, USA
  • Kraus, Virginia B
    • Other Affiliation: Department of Medicine, Duke Molecular Physiology Institute, School of Medicine, Duke University, Durham, USA
  • Jordan, Joanne
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology, School of Medicine, Thurston Arthritis Research Center, Department of Medicine, Division of Rheumatology, Allergy and Immunology
Abstract
  • Abstract Background Osteoarthritis (OA) prevalence differs by race. General joint hypermobility (GJH) may be associated with OA, but differences by race are not known. This community-based study examined the frequency of GJH and its relationship with knee, hip, and lumbar spine OA by race (African American vs. Caucasian). Methods Data were from the Johnston County OA project, collected 2003–2010. GJH was defined as Beighton score ≥4. OA symptoms were defined as the presence of pain, aching, or stiffness on most days separately at the knee, hip, and lower back. Radiographic OA (rOA) of the knee or hip was defined as Kellgren-Lawrence grade 2–4. Lumbar spine rOA was disc space narrowing grade ≥1 and osteophyte grade ≥2 in ≥ 1 at the same lumbar level. Lumbar spine facet rOA was present in ≥ 1 lumbar levels. Separate logistic regression models stratified by race were used to examine the association between hypermobility and rOA or OA symptoms at each joint site, adjusting for age, sex, previous joint injury, and body mass index (BMI). Results Of 1987 participants, 1/3 were African-American and 2/3 were women (mean age 65 years, mean BMI 31 kg/m2). Nearly 8% of Caucasians were hypermobile vs. 5% of African-Americans (p = 0.03). Hypermobility was associated with lower back symptoms in Caucasians (adjusted odds ratio (aOR) 1.54, 95% confidence interval (CI) 1.00, 2.39), but not in African-Americans (aOR 0.77, 95% CI 0.34, 1.72). Associations between hypermobility and other knee, hip, or lumbar spine/facet OA variables were not statistically significant. Conclusions General joint hypermobility was more common in Caucasians than African-Americans. Although there were no associations between hypermobility and rOA, the association between hypermobility and lower back symptoms may differ by race.
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Identifier
  • doi:10.1186/s13075-018-1570-7
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  • Article
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  • In Copyright
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  • The Author(s).
Language
  • English
Bibliographic citation
  • Arthritis Research & Therapy. 2018 Apr 18;20(1):76
Publisher
  • BioMed Central
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