Bidirectional signaling between the cytoskeleton and integrins Public Deposited
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- Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, School of Medicine, Department of Cell Biology and Physiology
Schoenwaelder, Simone M.
- Affiliation: School of Medicine, Department of Cell Biology and Physiology
- Clustering of integrins into focal adhesions and focal complexes is regulated by the actin cytoskeleton. In turn, actin dynamics are governed by Rho family GTPases. Integrin-mediated adhesion activates these GTPases, triggering assembly of filopodia, lamellipodia and stress fibers. In the past few years, signaling pathways have begun to be identified that promote focal adhesion disassembly and integrin dispersal. Many of these pathways result in decreased myosin-mediated cell contractility.
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- Current Opinion in Cell Biology
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|Bidirectional signaling between the cytoskeleton and integrins.pdf||2019-05-03||Public||