Bidirectional signaling between the cytoskeleton and integrins Public Deposited

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Creator
  • Burridge, Keith
    • Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, School of Medicine, Department of Cell Biology and Physiology
  • Schoenwaelder, Simone M.
    • Affiliation: School of Medicine, Department of Cell Biology and Physiology
Abstract
  • Clustering of integrins into focal adhesions and focal complexes is regulated by the actin cytoskeleton. In turn, actin dynamics are governed by Rho family GTPases. Integrin-mediated adhesion activates these GTPases, triggering assembly of filopodia, lamellipodia and stress fibers. In the past few years, signaling pathways have begun to be identified that promote focal adhesion disassembly and integrin dispersal. Many of these pathways result in decreased myosin-mediated cell contractility.
Date of publication
Identifier
  • 2-s2.0-0032911020
  • doi:10.1016/S0955-0674(99)80037-4
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Resource type
  • Journal Item
Rights statement
  • In Copyright
Journal title
  • Current Opinion in Cell Biology
Journal volume
  • 11
Journal issue
  • 2
Page start
  • 274
Page end
  • 286
Language
  • English
Version
  • Postprint
ISSN
  • 0955-0674
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