SARS-Like coronavirus WIV1-CoV does not replicate in Egyptian fruit bats (Rousettus aegyptiacus)

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  • van Doremalen, Neeltje
    • Other Affiliation: National Institutes of Health
  • Schäfer, Alexandra
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Menachery, Vineet D.
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Letko, Michael
    • Other Affiliation: National Institutes of Health
  • Bushmaker, Trenton
    • Other Affiliation: National Institutes of Health
  • Fischer, Robert J.
    • Other Affiliation: National Institutes of Health
  • Figueroa, Dania M.
    • Other Affiliation: National Institutes of Health
  • Hanley, Patrick W.
    • Other Affiliation: National Institutes of Health
  • Saturday, Greg
    • Other Affiliation: National Institutes of Health
  • Baric, Ralph S.
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Munster, Vincent J.
    • Other Affiliation: National Institutes of Health
Abstract
  • Severe acute respiratory syndrome (SARS)-like WIV1-coronavirus (CoV) was first isolated from Rhinolophus sinicus bats and can use the human angiotensin converting enzyme 2 (ACE2) receptor. In the current study, we investigate the ability of WIV1-CoV to infect Rousettus aegyptiacus bats. No clinical signs were observed throughout the experiment. Furthermore, only four oropharyngeal swabs and two respiratory tissues, isolated on day 3 post inoculation, were found positive for viral RNA. Two out of twelve bats showed a modest increase in coronavirus specific antibodies post challenge. In conclusion, WIV1-CoV was unable to cause a robust infection in Rousettus aegyptiacus bats.
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  • Article
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  • In Copyright
Journal title
  • Viruses
Journal volume
  • 10
Journal issue
  • 12
Language
  • English
ISSN
  • 1999-4915

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