Assessment of growth parameters and life span of GHR/BP gene-disrupted mice Public Deposited

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Creator
  • Kopchick, John J.
    • Other Affiliation: Edison Biotechnology Institute, Ohio University, Athens, Ohio 45701
  • Clemmons, David
    • Affiliation: School of Medicine, Department of Medicine, Division of Endocrinology and Metabolism
  • Bellush, Linda L.
    • Other Affiliation: Edison Biotechnology Institute, Ohio University, Athens, Ohio 45701
  • Coschigano, Karen T.
    • Other Affiliation: Edison Biotechnology Institute, Ohio University, Athens, Ohio 45701
Abstract
  • GH has many biological roles, including promotion of growth. Most, if not all, of its roles are achieved through interaction with its receptor. We chose to study the effects of loss of GH signaling on growth and aging in a mouse model for Laron Syndrome (LS) in which the GHR/BP gene has been disrupted. We observed that mice homozygous for the disruption (−/−) were significantly smaller than normal wild-type (+/+) mice as well as mice heterozygous for the disruption, even at 1.5 yr of age. IGF-I levels were also significantly lower in the −/− mice and remained low as the mice aged. IGFBP-3 levels were severely reduced in the −/− mice, whereas IGFBP-1, -2, and -4 levels remained unchanged. Finally, the −/− mice lived significantly longer than +/+ and +/− mice. The latter result contradicts the anti-aging GH data and suggests the need for further analysis of GH and aging.
Date of publication
Identifier
  • 2-s2.0-0034455827
  • doi:10.1210/en.141.7.2608
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Resource type
  • Article
Rights statement
  • In Copyright
Journal title
  • Endocrinology
Journal volume
  • 141
Journal issue
  • 7
Page start
  • 2608
Page end
  • 2613
Language
  • English
Version
  • Postprint
ISSN
  • 1945-7170
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