Cocaine locomotor activation, sensitization and place preference in six inbred strains of mice Public Deposited

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  • Eisener-Dorman, Amy F
    • Affiliation: School of Medicine, Department of Psychiatry
  • Grabowski-Boase, Laura
    • Other Affiliation: Genomics Institute of the Novartis Research Foundation, San Diego, CA, USA
  • Tarantino, Lisa
    • Affiliation: School of Medicine, Department of Psychiatry
  • Abstract Background The expanding set of genomics tools available for inbred mouse strains has renewed interest in phenotyping larger sets of strains. The present study aims to explore phenotypic variability among six commonly-used inbred mouse strains to both the rewarding and locomotor stimulating effects of cocaine in a place conditioning task, including several strains or substrains that have not yet been characterized for some or all of these behaviors. Methods C57BL/6J (B6), BALB/cJ (BALB), C3H/HeJ (C3H), DBA/2J (D2), FVB/NJ (FVB) and 129S1/SvImJ (129) mice were tested for conditioned place preference to 20 mg/kg cocaine. Results Place preference was observed in most strains with the exception of D2 and 129. All strains showed a marked increase in locomotor activity in response to cocaine. In BALB mice, however, locomotor activation was context-dependent. Locomotor sensitization to repeated exposure to cocaine was most significant in 129 and D2 mice but was absent in FVB mice. Conclusions Genetic correlations suggest that no significant correlation between conditioned place preference, acute locomotor activation, and locomotor sensitization exists among these strains indicating that separate mechanisms underlie the psychomotor and rewarding effects of cocaine.
Date of publication
  • doi:10.1186/1744-9081-7-29
  • 21806802
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • Amy F Eisener-Dorman et al.; licensee BioMed Central Ltd.
Journal title
  • Behavioral and Brain Functions
Journal volume
  • 7
Journal issue
  • 1
Page start
  • 29
  • English
Is the article or chapter peer-reviewed?
  • Yes
  • 1744-9081
Bibliographic citation
  • Behavioral and Brain Functions. 2011 Aug 01;7(1):29
  • Open Access
  • BioMed Central Ltd