Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women
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Li, Yu, et al. Cigarette Smoking, Cytochrome P4501a1 Polymorphisms, and Breast Cancer Among African-american and White Women. BioMed Central Ltd, 2004. https://doi.org/10.17615/szqr-hg20APA
Li, Y., Millikan, R., Bell, D., Cui, L., Tse, C., Newman, B., & Conway, K. (2004). Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women. BioMed Central Ltd. https://doi.org/10.17615/szqr-hg20Chicago
Li, Yu, Robert C Millikan, Douglas A Bell, Lisa Cui, Chiu Kit Tse, Beth Newman, and Kathleen Conway. 2004. Cigarette Smoking, Cytochrome P4501a1 Polymorphisms, and Breast Cancer Among African-American and White Women. BioMed Central Ltd. https://doi.org/10.17615/szqr-hg20- Creator
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Li, Yu
- Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
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Millikan, Robert C.
- Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
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Bell, Douglas A
- Other Affiliation: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
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Cui, Lisa
- Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
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Tse, Chiu-Kit
- Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
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Newman, Beth
- Other Affiliation: School of Public Health, Queensland University of Technology, Kelvin Grove, Australia
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Conway, Kathleen
- Affiliation: N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
- Abstract
- Introduction Previous epidemiologic studies suggest that women with variant cytochrome P4501A1 (CYP1A1) genotypes who smoke cigarettes are at increased risk for breast cancer. Methods We evaluated the association of breast cancer with CYP1A1 polymorphisms and cigarette smoking in a population-based, case–control study of invasive breast cancer in North Carolina. The study population consisted of 688 cases (271 African Americans and 417 whites) and 702 controls (285 African Americans and 417 whites). Four polymorphisms in CYP1A1 were genotyped using PCR/restriction fragment length polymorphism analysis: M1 (also known as CYP1A1*2A), M2 (CYP1A1*2C), M3 (CYP1A1*3), and M4 (CYP1A1*4) Results No associations were observed for CYP1A1 variant alleles and breast cancer, ignoring smoking. Among women who smoked for longer than 20 years, a modest positive association was found among women with one or more M1 alleles (odds ratio [OR] = 2.1, 95% confidence interval [CI] = 1.2–3.5) but not among women with non-M1 alleles (OR = 1.2, 95% CI = 0.9–1.6). Odds ratios for smoking longer than 20 years were higher among African-American women with one or more M3 alleles (OR = 2.5, 95% CI = 0.9–7.1) compared with women with non-M3 alleles (OR = 1.3, 95% CI = 0.8–2.2). ORs for smoking in white women did not differ appreciably based upon M2 or M4 genotypes. Conclusions Cigarette smoking increases breast cancer risk in women with CYP1A1 M1 variant genotypes and in African- American women with CYP1A1 M3 variant genotypes, but the modifying effects of the CYP1A1 genotype are quite weak.
- Date of publication
- June 15, 2004
- DOI
- Identifier
- 15217514
- https://doi.org/10.1186/bcr814
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Yu Li et al.; licensee BioMed Central Ltd.
- Journal title
- Breast Cancer Res
- Journal volume
- 6
- Journal issue
- 4
- Page start
- R460
- Page end
- R473
- Language
- English
- Is the article or chapter peer-reviewed?
- Yes
- ISSN
- 1465-5411
- Bibliographic citation
- Breast Cancer Research. 2004 Jun 15;6(4):R460-R473
- Publisher
- BioMed Central Ltd
- Access right
- Open Access
- Date uploaded
- January 27, 2017
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