Novel Insights into the Effects of Genetic Variants on Serum Urate Response to an Acute Fructose Challenge: A Pilot Study

Public Deposited
Analytics

Downloadable Content

Download PDF
Request Version for Screen Reader
Creator
  • Zhang, Xinruo
    • Affiliation: Gillings School of Global Public Health, Department of Nutrition
  • Mass, Baba B.
    • Affiliation: Gillings School of Global Public Health, Department of Nutrition
  • Talevi, Valentina
    • Affiliation: Gillings School of Global Public Health, Department of Nutrition
  • Hou, Ruixue
    • Affiliation: Gillings School of Global Public Health, Department of Nutrition
  • North, Kari E.
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Voruganti, Venkata Saroja
    • Affiliation: Gillings School of Global Public Health, Department of Nutrition
Abstract
  • Studies have shown that genetic variations can influence metabolic response to nutrient intake, and that diets rich in fructose contribute to hyperuricemia. In this pilot study, our aim was to determine the variability of serum urate in response to an acute fructose challenge and to investigate if genetic variants would affect this response in young to middle-aged adults who self-reported as Black or White. Fifty-seven participants consumed a fructose-rich beverage after an overnight fast. Blood was drawn at five time points (baseline, 30, 60, 120, and 180 min after consumption). Thirty urate-related single nucleotide polymorphisms (SNPs) were analyzed for their associations with baseline serum urate and its percent changes, using a two-step modeling approach followed by meta-analysis. At baseline, serum urate (mg/dL, mean ± SD) was higher in Whites (5.60 ± 1.01 vs. 5.37 ± 0.96), men (6.17 ± 1.14 vs. 5.24 ± 0.79), and those with obesity (5.69 ± 1.08 vs. 5.42 ± 1.06 vs. 5.34 ± 0.80). Three SNPs were significantly associated with baseline serum urate or its percent changes, and six SNPs were nominally associated with percent changes in serum urate. In summary, our results showed that genetic variants could play a role in short-term urate metabolism.
Date of publication
Keyword
DOI
Identifier
Resource type
  • Article
Rights statement
  • In Copyright
License
  • Attribution 4.0 International
Journal title
  • Nutrients
Journal volume
  • 14
Journal issue
  • 19
Page start
  • 4030
Language
  • English
Version
  • Publisher
ISSN
  • 2072-6643

Relations

Parents:

This work has no parents.

In Collection:

Items

Thumbnail Title Date Uploaded Visibility Actions
file details nutrients-14-04030.pdf 2022-10-07 Public Download