Tumor Evolution in Two Patients with Basal-like Breast Cancer: A Retrospective Genomics Study of Multiple Metastases

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  • Hoadley, Katherine A.
    • Affiliation: School of Medicine, Department of Genetics
    • Other Affiliation: University of North Carolina at Chapel Hill
  • Siegel, Marni B.
    • Affiliation: School of Medicine, Department of Genetics
    • Other Affiliation: University of North Carolina at Chapel Hill
  • Kanchi, Krishna L.
    • Other Affiliation: McDonnell Genome Institute; Washington University in St. Louis
  • Miller, Christopher A.
    • ORCID: 0000-0003-4266-6700
    • Other Affiliation: McDonnell Genome Institute; Washington University in St. Louis
  • Ding, Li
    • Other Affiliation: McDonnell Genome Institute; Washington University in St. Louis
  • Zhao, Wei
    • Affiliation: School of Medicine, Department of Genetics
    • Other Affiliation: University of North Carolina at Chapel Hill
  • He, Xiaping
    • Affiliation: University of North Carolina at Chapel Hill
  • Parker, Joel S.
    • Affiliation: School of Medicine, Department of Genetics
    • Other Affiliation: University of North Carolina at Chapel Hill
  • Wendl, Michael C.
    • Other Affiliation: Department of Mathematics; Washington University in St. Louis
  • Fulton, Robert S.
    • Other Affiliation: McDonnell Genome Institute; Washington University in St. Louis
  • Demeter, Ryan T.
    • Other Affiliation: McDonnell Genome Institute; Washington University in St. Louis
  • Wilson, Richard K.
    • ORCID: 0000-0002-1992-1358
    • Other Affiliation: McDonnell Genome Institute; Washington University in St. Louis
  • Carey, Lisa A.
    • Affiliation: School of Medicine, Department of Medicine
  • Perou, Charles M.
    • Affiliation: School of Medicine, Department of Genetics
    • Other Affiliation: University of North Carolina at Chapel Hill
  • Mardis, Elaine R.
    • Other Affiliation: McDonnell Genome Institute; Washington University in St. Louis
Abstract
  • Metastasis is the main cause of cancer patient deaths and remains a poorly characterized process. It is still unclear when in tumor progression the ability to metastasize arises and whether this ability is inherent to the primary tumor or is acquired well after primary tumor formation. Next-generation sequencing and analytical methods to define clonal heterogeneity provide a means for identifying genetic events and the temporal relationships between these events in the primary and metastatic tumors within an individual.
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  • Article
Rights statement
  • In Copyright
Journal title
  • PLoS Medicine
Journal volume
  • 13
Journal issue
  • 12
Page start
  • e1002174
Language
  • English
ISSN
  • 1549-1277
  • 1549-1676

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