Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case–control study of African Americans and whites Public Deposited

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Creator
  • Keku, Temitope
    • Affiliation: Center for Gastrointestinal Biology and Disease, School of Medicine
  • Player, Jon
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology, N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, School of Medicine
  • de Cotret, Allan R
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology, N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, School of Medicine
  • Millikan, Robert C.
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology, N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, School of Medicine
  • Tse, Chiu-Kit
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology, N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, School of Medicine
  • Pittman, Gary
    • Other Affiliation: National Institute of Environmental Health Sciences, North Carolina, USA
  • Moorman, Patricia
    • Other Affiliation: Department of Community and Family Medicine, Duke University, Medical Center, Durham, USA
  • Vannappagari, Vani
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology, N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, School of Medicine
Abstract
  • Abstract Introduction A polymorphism in the manganese superoxide dismutase (MnSOD) gene, Ala-9Val, has been examined in association with breast cancer risk in several epidemiologic studies. Results suggest that the Ala allele increases the risk of breast cancer and modifies the effects of environmental exposures that produce oxidative damage to DNA. Methods We examined the role of the MnSOD Ala-9Val polymorphism in a population-based case–control study of invasive and in situ breast cancer in North Carolina. Genotypes were evaluated for 2025 cases (760 African Americans and 1265 whites) and for 1812 controls (677 African Americans and 1135 whites). Results The odds ratio for MnSOD Ala/Ala versus any MnSOD Val genotypes was not elevated in African Americans (odds ratio = 0.9, 95% confidence interval = 0.7–1.2) or in whites (odds ratio = 1.0, 95% confidence interval = 0.8–1.2). Greater than additive joint effects were observed for the Ala/Ala genotype and smoking, radiation to the chest, and occupational exposure to ionizing radiation. Antagonism was observed between the Ala/Ala genotype and the use of nonsteroidal anti-inflammatory drugs. Conclusions The MnSOD genotype may contribute to an increased risk of breast cancer in the presence of specific environmental exposures. These results provide further evidence for the importance of reactive oxygen species and of oxidative DNA damage in the etiology of breast cancer.
Date of publication
Identifier
  • doi:10.1186/bcr786
Resource type
  • Article
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  • In Copyright
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  • Millikan et al., licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
Language
  • English
Bibliographic citation
  • Breast Cancer Research. 2004 Apr 07;6(4):R264
Publisher
  • BioMed Central
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