Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study

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  • Fesinmeyer, Megan D
    • Other Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4-B402, PO Box 19024, Seattle, WA 98109-1024, USA
  • North, Kari
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology, School of Medicine, Carolina Center for Genome Sciences
  • Lim, Unhee
    • Other Affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, 96813, USA
  • Bůžková, Petra
    • Other Affiliation: Department of Biostatistics, University of Washington, Seattle, USA
  • Crawford, Dana C
    • Other Affiliation: Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, 37203, USA
  • Haessler, Jeffrey
    • Other Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4-B402, PO Box 19024, Seattle, WA 98109-1024, USA
  • Gross, Myron D
    • Other Affiliation: Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA
  • Fowke, Jay H
    • Other Affiliation: Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, 37203, USA
  • Goodloe, Robert
    • Other Affiliation: Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, 37203, USA
  • Love, Shelly-Ann M
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Graff, Misa
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Carlson, Christopher S
    • Other Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4-B402, PO Box 19024, Seattle, WA 98109-1024, USA
  • Kuller, Lewis H
    • Other Affiliation: Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
  • Matise, Tara C
    • Other Affiliation: Department of Statistics & Biostatistics, Rutgers University, Piscataway, NJ, 08854, USA
  • Hong, Ching-Ping
    • Other Affiliation: Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA
  • Henderson, Brian E
    • Other Affiliation: Department of Preventive Medicine, Keck School of Medicine / Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
  • Allen, Melissa
    • Other Affiliation: Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, 37203, USA
  • Rohde, Rebecca R
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Mayo, Ping
    • Other Affiliation: Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, 37203, USA
  • Schnetz-Boutaud, Nathalie
    • Other Affiliation: Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, 37203, USA
  • Monroe, Kristine R
    • Other Affiliation: Department of Preventive Medicine, Keck School of Medicine / Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
  • Ritchie, Marylyn D
    • Other Affiliation: Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, 37203, USA
  • Prentice, Ross L
    • Other Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4-B402, PO Box 19024, Seattle, WA 98109-1024, USA
  • Kolonel, Lawrence N
    • Other Affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, 96813, USA
  • Manson, JoAnn E
    • Other Affiliation: Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA
  • Pankow, James
    • Other Affiliation: Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA
  • Hindorff, Lucia A
    • Other Affiliation: Office of Population Genomics, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
  • Franceschini, Nora
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Wilkens, Lynne R
    • Other Affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, 96813, USA
  • Haiman, Christopher A
    • Other Affiliation: Department of Preventive Medicine, Keck School of Medicine / Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
  • Le Marchand, Loic
    • Other Affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, 96813, USA
  • Peters, Ulrike
    • Other Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4-B402, PO Box 19024, Seattle, WA 98109-1024, USA
Abstract
  • Abstract Background Although smoking behavior is known to affect body mass index (BMI), the potential for smoking to influence genetic associations with BMI is largely unexplored. Methods As part of the ‘Population Architecture using Genomics and Epidemiology (PAGE)’ Consortium, we investigated interaction between genetic risk factors associated with BMI and smoking for 10 single nucleotide polymorphisms (SNPs) previously identified in genome-wide association studies. We included 6 studies with a total of 56,466 subjects (16,750 African Americans (AA) and 39,716 European Americans (EA)). We assessed effect modification by testing an interaction term for each SNP and smoking (current vs. former/never) in the linear regression and by stratified analyses. Results We did not observe strong evidence for interactions and only observed two interactions with p-values <0.1: for rs6548238/TMEM18, the risk allele (C) was associated with BMI only among AA females who were former/never smokers (β = 0.018, p = 0.002), vs. current smokers (β = 0.001, p = 0.95, pinteraction = 0.10). For rs9939609/FTO, the A allele was more strongly associated with BMI among current smoker EA females (β = 0.017, p = 3.5x10-5), vs. former/never smokers (β = 0.006, p = 0.05, pinteraction = 0.08). Conclusions These analyses provide limited evidence that smoking status may modify genetic effects of previously identified genetic risk factors for BMI. Larger studies are needed to follow up our results. Clinical Trial Registration NCT00000611
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Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • Megan D Fesinmeyer et al.; licensee BioMed Central Ltd.
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Journal title
  • BMC Medical Genetics
Journal volume
  • 14
Journal issue
  • 1
Page start
  • 6
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1471-2350
Bibliographic citation
  • BMC Medical Genetics. 2013 Jan 11;14(1):6
Publisher
  • BioMed Central Ltd
Access right
  • Open Access
Date uploaded
  • February 6, 2013

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