Six-month humoral immune response to inactivated COVID-19 vaccine among people living with HIV
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Zou, Shi, et al. Six-month Humoral Immune Response to Inactivated Covid-19 Vaccine Among People Living with Hiv. 2022. https://doi.org/10.17615/2kzw-tn70APA
Zou, S., Guo, W., Wu, S., Ming, F., Tan, Y., Wu, M., Tang, W., & Liang, K. (2022). Six-month humoral immune response to inactivated COVID-19 vaccine among people living with HIV. https://doi.org/10.17615/2kzw-tn70Chicago
Zou, Shi, Wei Guo, Songjie Wu, Fangzhao Ming, Yuting Tan, Mengmeng Wu, Weiming Tang et al. 2022. Six-Month Humoral Immune Response to Inactivated Covid-19 Vaccine Among People Living with Hiv. https://doi.org/10.17615/2kzw-tn70- Creator
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Zou, Shi
- Other Affiliation: Zhongnan Hospital of Wuhan University
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Guo, Wei
- Other Affiliation: Zhongnan Hospital of Wuhan University
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Wu, Songjie
- Other Affiliation: Zhongnan Hospital of Wuhan University
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Ming, Fangzhao
- Other Affiliation: Wuchang District Center for Disease Control and Prevention
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Tan, Yuting
- Other Affiliation: Zhongnan Hospital of Wuhan University
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Wu, Mengmeng
- Other Affiliation: Zhongnan Hospital of Wuhan University
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Tang, Weiming
- Affiliation: School of Medicine, UNC Project-China
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Liang, Ke
- Other Affiliation: Zhongnan Hospital of Wuhan University
- Abstract
- Longitudinal humoral immune response to inactivated COVID-19 vaccines among people living with HIV (PLWH) have not yet been systematically investigated. We conducted a 6-month longitudinal study among vaccinated PLWH and HIV-Negative Controls (HNC) to determine whether the humoral immune response effects of the inactivated COVID-19 vaccine are different between the two groups of people. Totally, 46 PLWH and 38 HNC who received the inactivated COVID-19 vaccine on days 0 and 28 were enrolled. The SARS-CoV-2 neutralizing antibodies (nAbs) and total specific IgM and IgG antibodies were examined on Day 0-Day190. The level and positive seroconversion rate of nAbs peaked on Day 42 in HNC while peaked on Day 70 in PLWH, then decreased gradually with the extension of the vaccination period after the peaks. The peak level of nAbs in PLWH on Day 70, (GMC 8.07 BAU/mL, 95% CI 5.67-11.48) was significantly lower than in HNC on Day 42 (GMC 18.28 BAU/mL, 95% CI 10.33-32.33, P =0.03). The decrease in the geometric mean concentrations (GMCs) of nAbs was observed as 42.9% in PLWH after peak level, which decreased from 8.07 BAU/mL [95% CI: 5.67-11.48] on Day 70 to 4.61 BAU/mL [95% CI: 3.35-6.34] on Day 190 (p = 0.02). On Day 190, only seven (18%, [95% CI: 6-40]) HNC and five (11%, [95% CI: 4-25]) PLWH maintained positive nAbs response respectively. The geometric mean ELISA units (GMEUs) and positive seroconversion rate of IgG in PLWH dropped significantly from Day 70 (GMEUs, 0.20 EU/mL, [95% CI: 0.13-0.34]; seroconversion, 52%, [95% CI: 34-69]) to Day 190 (GMEUs, 0.05 EU/mL, [95% CI: 0.03-0.08], P<0.001; seroconversion, 18%, [95% CI: 8-33], P<0.001). There was no significant difference in levels and seroconversion rates of nAbs and IgG between the two groups on Day 190. The peak immunogenicity of the inactivated COVID-19 vaccine was delayed and inferior in PLWH compared to HNC, while no significant difference was found in six-month immunogenicity between the two groups.
- Date of publication
- 2022
- Keyword
- DOI
- Identifier
- Resource type
- Article
- License
- Attribution 4.0 International
- Journal title
- Frontiers in Immunology
- Journal volume
- 13
- Language
- English
- Version
- Publisher
- Funder
- National Key Research and Development Program of China (2017YFE0103800)
- Discipline Cultivation Project of Department of Infectious Diseases, Zhongnan Hospital, Wuhan University (ZNXKPY2021027)
- Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University(TFJC2018004)
- Science and Technology Innovation Cultivation Fund of Zhongnan Hospital, Wuhan University (cxpy2017043)
- Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2020-PT320-004)
- Medical Science and Technology Innovation Platform Support Project of Zhongnan Hospital, Wuhan University (PTXM2020008)
- Special Found onPrevention and Control of New Coronary Pneumonia in Guangdong Universities (2020KZDZX1047)
- National Nature Science Foundation of China (81903371)
- NIMH (R34MH119963)
- National Science and Technology Major Project (2018ZX10101-001-001-003)
- ISSN
- 1664-3224
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