Cell Cycle Controls: Potential Targets for Chemical Carcinogens?
Public Deposited- Creator
- Afshari, C A
- Barrett, J C
- Abstract
- The progression of the cell cycle is controlled by the action of both positive and negative growth regulators. The key players in this activity include a family of cyclins and cyclin-dependent kinases, which are themselves regulated by other kinases and phosphatases. Maintenance of balanced cell cycle controls may be directly linked to genomic stability. Loss of the check-points involved in cell cycle control may result in unrepaired DNA damage during DNA synthesis or mitosis leading to genetic mutations and contributing to carcinogenesis.
- Date of publication
- 1993
- Keyword
- DOI
- Identifier
- Onescience id: 3df813d6a8538fc5b7ed8694a877519cb439ad97
- Publisher DOI: https://doi.org/10.1289/ehp.93101s59
- PMCID: PMC1519451
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Environmental Health Perspectives
- Journal volume
- 101
- Journal issue
- Suppl 5
- Page start
- 9
- Page end
- 14
- Language
- English
- ISSN
- 1552-9924
- 0091-6765
Relations
- Parents:
This work has no parents.
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