Genetic and dietary determinants of insulin-like growth factor (igf)-1 and igf binding protein (bp)-3 levels among chinese women
Public Deposited- Creator
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Wang, Q
- Other Affiliation: Sun Yat-Sen University
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Liu, L.
- Other Affiliation: Chengdu Women's and Children's Central Hospital
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Li, H.
- Other Affiliation: Sichuan University
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McCullough, L.E.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Qi, Y.-N.
- Other Affiliation: Sichuan University
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Li, J.-Y.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Zhang, J.
- Other Affiliation: Chengdu Women's and Children's Central Hospital
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Miller, E.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
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Yang, C.-X.
- Other Affiliation: Sichuan University
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Smith, J.S.
- Affiliation: Gillings School of Global Public Health, Department of Epidemiology
- Abstract
- Background: Higher insulin-like growth factor (IGF)-1 and lower IGF binding protein (BP)-3 levels have been associated with higher commoncancer risk, including breast cancer. Dietary factors, genetic polymorphisms, and the combination of both may influence circulating IGF-1 and IGFBP-3 serum concentrations.Methods: From September 2011 to July 2012, we collected demographic, reproductive and dietary data on 143 women (> 40 years). We genotyped IGF-1 rs1520220 and IGFBP-3 rs2854744 and measured circulating IGF-1 and IGFBP-3 levels in serum. Covariance analyses were used to estimate the associations of serum levels of IGF-1 and IGFBP-3, and the molar ratio of IGF-1to IGFBP-3 with IGF-1 rsl 520220 and IGFBP-3 rs2854744 genotypes. We subsequently assessed the combined influence of genetics and diet (daily intake of protein, fat and soy isoflavones) on IGF-1 and IGFBP-3 levels.Results: Among women aged less than 50 years, circulating IGF-1 serum levels were significantly lower for those with CC genotype for IGF-1 rsl 520220 than levels for those with the GC or GG genotypes (in recessive model: P = 0.007).ln gene-diet analyses among these women, we found carrying CC genotype for IGF-1 rs1520220 and high soy isoflavone intake tend to be associated with lower circulating IGF-1 levels synthetically (P = 0.002). Women with GG or GC genotypes for IGF-1 rsl 520220 and with low intake of soy isoflavones had the highest levels of circulating IGF-1 (geometric mean [95% Cl]: 195 [37, 1021] μg/L). Comparatively, women with both the CC genotype and high soy intake had the lowest levels of circulating IGF-1 (geometric mean [95% Cl]: 120 [38,378] μg/L).Conclusions: IGF-1 serum levels are significantly lower among women with the CC genotype for IGF-1-rs1 520220. High soy isoflavone intake may interact with carrying CC genotype for IGF-1-rs1 520220 to lower women's serum IGF-1 levels more.
- Date of publication
- 2014
- Keyword
- demography
- risk assessment
- cancer risk
- adolescent
- Female
- diet
- Asian Continental Ancestry Group
- protein function
- reproduction
- normal human
- IGF 1 gene
- genetic risk
- protein blood level
- genetic polymorphism
- genotype
- middle aged
- Isoflavones
- Article
- disease association
- Insulin-Like Growth Factor I
- adult
- Adolescent
- IGFBP 3 gene
- Asian continental ancestry group
- Humans
- single nucleotide polymorphism
- protein intake
- somatomedin C
- Diet
- Reproduction
- human
- China
- Insulin-Like Growth Factor Binding Protein 3
- blood
- Polymorphism, Single Nucleotide
- isoflavone derivative
- genetics
- protein determination
- Adult
- Middle Aged
- somatomedin binding protein 3
- female
- Chinese
- protein expression
- Demography
- DOI
- Identifier
- Resource type
- Article
- License
- Attribution 4.0 International
- Journal title
- PLoS ONE
- Journal volume
- 9
- Journal issue
- 10
- Language
- English
- Version
- Publisher
- ISSN
- 1932-6203
- Publisher
- Public Library of Science
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