Associations of coronary artery calcified plaque density with mortality in type 2 diabetes: the Diabetes Heart Study

Public Deposited
Analytics

Downloadable Content

Download PDF
Request Version for Screen Reader
Creator
  • Raffield, Laura M
    • Affiliation: School of Medicine, Department of Genetics
    • Other Affiliation: Wake Forest School of Medicine
  • Cox, Amanda J
    • Other Affiliation: Wake Forest School of Medicine
  • Criqui, Michael H
    • Other Affiliation: University of California, San Diego
  • Hsu, Fang-Chi
    • Other Affiliation: Wake Forest School of Medicine
  • Terry, James G
    • Other Affiliation: Vanderbilt University
  • Xu, Jianzhao
    • Other Affiliation: Wake Forest School of Medicine
  • Freedman, Barry I
    • Other Affiliation: Wake Forest School of Medicine
  • Carr, J. J
    • Other Affiliation: Vanderbilt University
  • Bowden, Donald W
    • Other Affiliation: Wake Forest School of Medicine
Abstract
  • Background Coronary artery calcified plaque (CAC) is strongly predictive of cardiovascular disease (CVD) events and mortality, both in general populations and individuals with type 2 diabetes at high risk for CVD. CAC is typically reported as an Agatston score, which is weighted for increased plaque density. However, the role of CAC density in CVD risk prediction, independently and with CAC volume, remains unclear. Methods We examined the role of CAC density in individuals with type 2 diabetes from the family-based Diabetes Heart Study and the African American-Diabetes Heart Study. CAC density was calculated as mass divided by volume, and associations with incident all-cause and CVD mortality [median follow-up 10.2 years European Americans (n = 902, n = 286 deceased), 5.2 years African Americans (n = 552, n = 93 deceased)] were examined using Cox proportional hazards models, independently and in models adjusted for CAC volume. Results In European Americans, CAC density, like Agatston score and volume, was consistently associated with increased risk of all-cause and CVD mortality (p ≤ 0.002) in models adjusted for age, sex, statin use, total cholesterol, HDL, systolic blood pressure, high blood pressure medication use, and current smoking. However, these associations were no longer significant when models were additionally adjusted for CAC volume. CAC density was not significantly associated with mortality, either alone or adjusted for CAC volume, in African Americans. Conclusions CAC density is not associated with mortality independent from CAC volume in European Americans and African Americans with type 2 diabetes.
Date of publication
DOI
Identifier
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • The Author(s)
Journal title
  • Cardiovascular Diabetology
Journal volume
  • 17
Journal issue
  • 1
Language
  • English
Bibliographic citation
  • Cardiovascular Diabetology. 2018 May 11;17(1):67
Publisher
  • BioMed Central

Relations

Parents:

This work has no parents.

Items

Thumbnail Title Date Uploaded Visibility Actions
file details 12933_2018_article_714.pdf 2019-05-07 Public Download
file details 12933_2018_714_moesm1_esm.docx 2019-05-07 Public Download