Nasal and Plasma SARS-CoV-2 RNA Levels are Associated with Timing of Symptom Resolution in the ACTIV-2 Trial of Non-hospitalized Adults with COVID-19

Public Deposited
Analytics

Downloadable Content

Download PDF
Request Version for Screen Reader
Creator
  • Li, Yijia
    • Other Affiliation: Harvard Medical School
  • Harrison, Linda J
    • Other Affiliation: Harvard T.H. Chan School of Public Health
  • Chew, Kara W
    • Other Affiliation: University of California, Los Angeles
  • Currier, Judy S
    • Other Affiliation: University of California, Los Angeles
  • Wohl, David A
    • Affiliation: School of Medicine
  • Daar, Eric S
    • Other Affiliation: Harbor-UCLA Medical Center
  • Evering, Teresa H
    • Other Affiliation: Weill Cornell Medical College
  • Wu, Ryan
    • Other Affiliation: Harvard T.H. Chan School of Public Health
  • Giganti, Mark
    • Other Affiliation: Harvard T.H. Chan School of Public Health
  • Ritz, Justin
    • Other Affiliation: Harvard T.H. Chan School of Public Health
  • Javan, Arzhang Cyrus
    • Other Affiliation: National Institutes of Health
  • Coombs, Robert
    • Other Affiliation: University of Washington
  • Moser, Carlee
    • Other Affiliation: Harvard T.H. Chan School of Public Health
  • Hughes, Michael D
    • Other Affiliation: Harvard T.H. Chan School of Public Health
  • Eron, Joseph J
    • Affiliation: School of Medicine
  • Smith, Davey M
    • Other Affiliation: University of California, San Diego
  • Li, Jonathan Z
    • Other Affiliation: Harvard Medical School
Abstract
  • Acute COVID-19 symptoms limit daily activities, but little is known about its association with SARS-CoV-2 viral burden. In this exploratory analysis of placebo recipients in the ACTIV-2/A5401 platform trial, we showed that high anterior nasal (AN) RNA levels and detectable plasma RNA were associated with delayed symptom improvement.
Date of publication
Keyword
DOI
Identifier
Resource type
  • Article
Journal title
  • Clinical Infectious Diseases
Language
  • English
Version
  • Postprint
ISSN
  • 1058-4838

Relations

Parents:

This work has no parents.

In Collection:

Items

Thumbnail Title Date Uploaded Visibility Actions
file details ciac818.pdf 2022-11-04 Public Download