HIV-associated salivary gland disease: a role for BK birus Public Deposited

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Creator
  • Jeffers, Liesl
    • Affiliation: School of Medicine, Department of Microbiology and Immunology
  • Webster-Cyriaque, Jennifer
    • Affiliation: School of Medicine, Department of Microbiology and Immunology, Division of Infectious Diseases, School of Dentistry, Department of Dental Ecology, N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center
Abstract
  • HIV-associated salivary gland disease (HIV-SGD) is disfiguring and causes significant morbidity in the HIV population. Evidence detailing the epidemiology of HIV-SGD suggests the involvement of a viral opportunist in its pathogenesis, yet the specific etiology of HIV-SGD remains unclear. To determine the role for an opportunistic virus as the etiologic agent of HIV-SGD, we hypothesized that HIV-SGD was a manifestation of primary infection or reactivation with a DNA tumor virus, BKV, during immune suppression. The central hypothesis of this work is that viral pathogenesis is essential to the development of salivary gland disease. Results show for the first time that polyomavirus, BKV, is associated with HIV-SGD. BKV DNA, RNA, and protein were consistently detected in salivary gland biopsies and in the peripheral blood and oral fluids from HIV-SGD patients and not in control subjects.
Date of publication
Identifier
  • doi:10.1186/1750-9378-5-S1-A33
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • Liesl Jeffers et al.; licensee BioMed Central Ltd.
Journal title
  • Infectious Agents and Cancer
Journal volume
  • 5
Journal issue
  • Suppl 1
Page start
  • A33
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1750-9378
Bibliographic citation
  • Infectious Agents and Cancer. 2010 Oct 11;5(Suppl 1):A33
Access
  • Open Access
Publisher
  • BioMed Central Ltd
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