Molecular portraits of human breast tumours

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  • Perou, Charles M.
  • Sorlie, Therese
    • Other Affiliation: Department of Genetics, The Norwegian Radium Hospital, N-0310 Montebello Oslo, Norway
  • Eisen, Michael B.
    • Other Affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA
  • van de Rijn, Matt
    • Other Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
  • Jeffrey, Stefanie S.
    • Other Affiliation: Department of Surgery, Stanford University School of Medicine, Stanford, California 94305 , USA
  • Rees, Christian A.
    • Other Affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA
  • Pollack, Jonathan R.
    • Other Affiliation: Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305, USA
  • Ross, Douglas T.
    • Other Affiliation: Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305, USA
  • Johnsen, Hilde
    • Other Affiliation: Department of Genetics, The Norwegian Radium Hospital, N-0310 Montebello Oslo, Norway
  • Akslen, Lars A.
    • Other Affiliation: Department of Pathology, The Gade Institute, Haukeland University Hospital, N-5021 Bergen, Norway
  • Fluge, Oystein
    • Other Affiliation: Department of Molecular Biology, University of Bergen, N-5020 Bergen, Norway
  • Pergamenschikov, Alexander
    • Other Affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA
  • Williams, Cheryl
    • Other Affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA
  • Zhu, Shirley X.
    • Other Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
  • Lonning, Per E.
    • Other Affiliation: Department of Oncology, Haukeland University Hospital, N-5021 Bergen, Norway
  • Borresen-Dale, Anne-Lise
    • Other Affiliation: Department of Genetics, The Norwegian Radium Hospital, N-0310 Montebello Oslo, Norway
  • Brown, Patrick O.
    • Other Affiliation: Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
  • Botstein, David
    • Other Affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA
Abstract
  • Human breast tumours are diverse in their natural history and in their responsiveness to treatments1. Variation in transcriptional programs accounts for much of the biological diversity of human cells and tumours. In each cell, signal transduction and regulatory systems transduce information from the cell's identity to its environmental status, thereby controlling the level of expression of every gene in the genome. Here we have characterized variation in gene expression patterns in a set of 65 surgical specimens of human breast tumours from 42 different individuals, using complementary DNA microarrays representing 8,102 human genes. These patterns provided a distinctive molecular portrait of each tumour. Twenty of the tumours were sampled twice, before and after a 16-week course of doxorubicin chemotherapy, and two tumours were paired with a lymph node metastasis from the same patient. Gene expression patterns in two tumour samples from the same individual were almost always more similar to each other than either was to any other sample. Sets of co-expressed genes were identi®ed for which variation in messenger RNA levels could be related to speci®c features of physiological variation. The tumours could be classi®ed into subtypes distinguished by pervasive differences in their gene expression patterns.
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  • Article
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  • In Copyright
Journal title
  • Nature
Journal volume
  • 406
Journal issue
  • 6797
Language
  • English
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  • Postprint

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