The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods

Public Deposited
Analytics

Downloadable Content

Download PDF
Request Version for Screen Reader
Creator
  • Thornton, L.M.
    • University of North Carolina at Chapel Hill
  • Munn-Chernoff, M.A.
    • University of North Carolina at Chapel Hill
  • Baker, J.H.
    • University of North Carolina at Chapel Hill
  • Juréus, A.
    • Other Affiliation: Karolinska Institutet
  • Parker, R.
    • Other Affiliation: Royal Brisbane Hospital
  • Henders, A.K.
    • Other Affiliation: The University of Queensland
  • Larsen, J.T.
    • Other Affiliation: Aarhus University
  • Petersen, L.
    • Other Affiliation: Aarhus University
  • Watson, H.J.
    • University of North Carolina at Chapel Hill
  • Yilmaz, Z.
    • University of North Carolina at Chapel Hill
  • Kirk, K.M.
    • Other Affiliation: Royal Brisbane Hospital
  • Gordon, S.
    • Other Affiliation: Royal Brisbane Hospital
  • Leppä, V.M.
    • Other Affiliation: Karolinska Institutet
  • Martin, F.C.
    • Other Affiliation: Royal Brisbane Hospital
  • Whiteman, D.C.
    • Other Affiliation: Royal Brisbane Hospital
  • Olsen, C.M.
    • Other Affiliation: Royal Brisbane Hospital
  • Werge, T.M.
    • Other Affiliation: University of Copenhagen
  • Pedersen, N.L.
    • Other Affiliation: Karolinska Institutet
  • Kaye, W.
    • Other Affiliation: University of California San Diego
  • Bergen, A.W.
    • Other Affiliation: Oregon Research Institute
  • Halmi, K.A.
    • Other Affiliation: Weill Cornell Medical College
  • Strober, M.
    • Other Affiliation: University of California at Los Angeles
  • Kaplan, A.S.
    • Other Affiliation: University of Toronto
  • Woodside, D.B.
    • Other Affiliation: University of Toronto
  • Mitchell, J.
    • Other Affiliation: Neuropsychiatric Research Institute
  • Johnson, C.L.
    • Other Affiliation: Eating Recovery Center
  • Brandt, H.
    • Other Affiliation: The Center for Eating Disorders at Sheppard Pratt
  • Crawford, S.
    • Other Affiliation: The Center for Eating Disorders at Sheppard Pratt
  • Horwood, L.J.
    • Other Affiliation: University of Otago
  • Boden, J.M.
    • Other Affiliation: University of Otago
  • Pearson, J.F.
    • Other Affiliation: University of Otago
  • Duncan, L.E.
    • Other Affiliation: Stanford University
  • Grove, J.
    • Other Affiliation: Aarhus University
  • Mattheisen, M.
    • Other Affiliation: Aarhus University
  • Jordan, J.
    • Other Affiliation: University of Otago
  • Kennedy, M.A.
    • Other Affiliation: University of Otago
  • Birgegård, A.
    • Other Affiliation: Karolinska Institutet
  • Lichtenstein, P.
    • Other Affiliation: Karolinska Institutet
  • Norring, C.
    • Other Affiliation: Karolinska Institutet
  • Wade, T.D.
    • Other Affiliation: Flinders University
  • Montgomery, G.W.
    • Other Affiliation: The University of Queensland
  • Martin, N.G.
    • Other Affiliation: Royal Brisbane Hospital
  • Landén, M.
    • Other Affiliation: Gothenburg University
  • Mortensen, P.B.
    • Other Affiliation: University of Copenhagen
  • Sullivan, P.F.
    • University of North Carolina at Chapel Hill
  • Bulik, C.M.
    • University of North Carolina at Chapel Hill
Abstract
  • Background: Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN and ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research. Methods: ANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H. Results: Blood samples and clinical information were collected from 13,363 individuals with lifetime AN and from controls. Online diagnostic phenotyping was effective and efficient; the validity of the questionnaire was acceptable. Conclusions: Our multi-pronged recruitment approach was highly effective for rapid recruitment and can be used as a model for efforts by other groups. High online presence of individuals with AN rendered the Internet/social media a remarkably effective recruitment tool in some countries. ANGI has substantially augmented Psychiatric Genomics Consortium AN sample collection. ANGI is a registered clinical trial: clinicaltrials.govNCT01916538; https://clinicaltrials.gov/ct2/show/NCT01916538?cond=Anorexia+Nervosa&draw=1&rank=3.
Date of publication
Keyword
DOI
Identifier
Resource type
  • Article
Rights statement
  • In Copyright
Journal title
  • Contemporary Clinical Trials
Journal volume
  • 74
Page start
  • 61
Page end
  • 69
Language
  • English
ISSN
  • 1551-7144
Publisher
  • Elsevier Inc.

Relations

Parents:

This work has no parents.

In Collection:

Items

Thumbnail Title Date Uploaded Visibility Actions
file details 1-s2.0-S1551714418302751-main.pdf 2021-01-26 Public Download