AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV
Public Deposited- Creator
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Bhatt, Aadra P.
- Affiliation: University of North Carolina at Chapel Hill
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Damania, Blossom
- Affiliation: University of North Carolina at Chapel Hill
- Abstract
- As an obligate intracellular parasite, Kaposi sarcoma-associated herpesvirus (KSHV) relies on the host cell machinery to meet its needs for survival, viral replication, production, and dissemination of progeny virions. KSHV is a gammaherpesvirus that is associated with three different malignancies: Kaposi sarcoma (KS), and two B cell lymphoproliferative disorders, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. KSHV viral proteins modulate the cellular phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway, which is a ubiquitous pathway that also controls B lymphocyte proliferation and development. We review the mechanisms by which KSHV manipulates the PI3K/AKT/mTOR pathway, with a specific focus on B cells.
- Date of publication
- 2013
- Keyword
- DOI
- Identifier
- PMCID: PMC3539662
- Onescience id: 064761442b787a837e5412fe25aaa702a95c23f8
- Publisher DOI: https://doi.org/10.3389/fimmu.2012.00401
- PMID: 23316192
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Frontiers in Immunology
- Journal volume
- 3
- Journal issue
- jan
- Language
- English
- ISSN
- 1664-3224
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