Hepatitis C Virus Induces MDSCs-Like Monocytes through TLR2/PI3K/AKT/STAT3 Signaling

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Zhai, Naicui
- Other Affiliation: Institute of Translational Medicine; First Hospital; Jilin University
Li, Haijun
- Other Affiliation: Institute of Translational Medicine; First Hospital; Jilin University
Song, Hongxiao
- Other Affiliation: Institute of Translational Medicine; First Hospital; Jilin University
Yang, Yang
- Other Affiliation: Institute of Translational Medicine; First Hospital; Jilin University
Cui, An
- Other Affiliation: Institute of Translational Medicine; First Hospital; Jilin University
Li, Tianyang
- Other Affiliation: Institute of Translational Medicine; First Hospital; Jilin University
Niu, Junqi
- Other Affiliation: Department of Hepatobiliary and Pancreatic Diseases; First Hospital; Jilin University
Crispe, Ian Nicholas
- Other Affiliation: Department of Pathology; University of Washington
Su, Lishan
- Affiliation: School of Medicine
- Other Affiliation: Institute of Translational Medicine; First Hospital; Jilin University
Tu, Zhengkun
- Other Affiliation: Department of Hepatobiliary and Pancreatic Diseases; First Hospital; Jilin University

Abstract

Recent studies reveal the accumulation of myeloid derived suppressor cells (MDSCs) in human peripheral blood mononuclear cells (PBMCs) following HCV infection, which may facilitate and maintain HCV persistent infection. The mechanisms by which HCV induces MDSCs are poorly understood. In the present study, we investigated the mechanisms by which HCV induces MDSCs that lead to suppression of T cell proliferation and expansion of CD4+Foxp3+ regulatory T cells.

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