Epidemiology of Barrett’s Esophagus and Esophageal Adenocarcinoma Public Deposited

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Creator
  • Runge, Thomas M.
  • Abrams, Julian A.
  • Shaheen, Nicholas J.
Abstract
  • Barrett’s esophagus (BE) is a common condition, and is the precursor to esophageal adenocarcinoma, a disease with increasing burden in the western world, especially in Caucasian males. The incidence of BE increased dramatically during the late-20th century and incidence estimates continue to increase, with a prominent male:female ratio. The prevalence is between 0.5 – 2.0 percent. A number of anthropomorphic and behavioral risk factors exist for BE including obesity and tobacco smoking, but GERD is the strongest risk factor, and the risk is more pronounced with long-standing GERD. Esophageal adenocarcinoma (EAC) is the most common form of esophageal cancer in the U.S. Risk factors include GERD, tobacco smoking, and obesity, while NSAIDs and statins may be protective. A major factor predicting progression from non-dysplastic BE to EAC is the presence of dysplastic changes seen on esophageal histology, although a number of issues limit the utility of dysplasia as a marker for disease. Length of the involved BE segment is another risk for progression to high-grade dysplasia and cancer. Biomarkers have shown promise, but none are approved for clinical use.
Date of publication
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DOI
Identifier
Resource type
  • Article
Rights statement
  • In Copyright
Journal title
  • Gastroenterology Clinics of North America
Journal volume
  • 44
Journal issue
  • 2
Page start
  • 203
Page end
  • 231
Language
  • English
ISSN
  • 1558-1942
  • 0889-8553
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