The NLRP3 inflammasome: molecular activation and regulation to therapeutics

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  • Swanson, K.V.
    • School of Medicine, Department of Medicine
  • Deng, M.
    • Adams School of Dentistry
  • Ting, J.P.-Y.
    • School of Medicine, Department of Genetics
Abstract
  • NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an intracellular sensor that detects a broad range of microbial motifs, endogenous danger signals and environmental irritants, resulting in the formation and activation of the NLRP3 inflammasome. Assembly of the NLRP3 inflammasome leads to caspase 1-dependent release of the pro-inflammatory cytokines IL-1β and IL-18, as well as to gasdermin D-mediated pyroptotic cell death. Recent studies have revealed new regulators of the NLRP3 inflammasome, including new interacting or regulatory proteins, metabolic pathways and a regulatory mitochondrial hub. In this Review, we present the molecular, cell biological and biochemical bases of NLRP3 activation and regulation and describe how this mechanistic understanding is leading to potential therapeutics that target the NLRP3 inflammasome.
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  • Article
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  • In Copyright
Journal title
  • Nature Reviews Immunology
Journal volume
  • 19
Journal issue
  • 8
Page start
  • 477
Page end
  • 489
Language
  • English
ISSN
  • 1474-1733
Publisher
  • Nature Publishing Group

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