Neurodevelopmental effects of insulin-like growth factor signaling
Public Deposited- Creator
-
O'Kusky, John
- Other Affiliation: The University of British Columbia
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Ye, Ping
- Affiliation: University of North Carolina at Chapel Hill
- Abstract
- Insulin-like growth factor (IGF) signaling greatly impacts the development and growth of the central nervous system (CNS). IGF-I and IGF-II, two ligands of the IGF system, exert a wide variety of actions both during development and in adulthood, promoting the survival and proliferation of neural cells. The IGFs also influence the growth and maturation of neural cells, augmenting dendritic growth and spine formation, axon outgrowth, synaptogenesis, and myelination. Specific IGF actions, however, likely depend on cell type, developmental stage, and local microenvironmental milieu within the brain. Emerging research also indicates that alterations in IGF signaling likely contribute to the pathogenesis of some neurological disorders. This review summarizes experimental studies and shed light on the critical roles of IGF signaling, as well as its mechanisms, during CNS development.
- Date of publication
- 2012
- Keyword
- DOI
- Identifier
- Onescience id: 5f5f56f2ce25b20f210f6ad2776935d0e77feacf
- PMID: 22710100
- PMCID: PMC3677055
- Publisher DOI: https://doi.org/10.1016/j.yfrne.2012.06.002
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- Frontiers in Neuroendocrinology
- Journal volume
- 33
- Journal issue
- 3
- Page start
- 230
- Page end
- 251
- Language
- English
- ISSN
- 0532-7466
- 1095-6808
- 0091-3022
Relations
- Parents:
- In Collection:
This work has no parents.
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