Nutritional regulation of IGF-I and IGF binding proteins Public Deposited

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Creator
  • Clemmons, David
    • Affiliation: School of Medicine, Department of Medicine, Division of Endocrinology and Metabolism
  • Underwood, Louis E.
    • Affiliation: School of Medicine, Department of Pediatrics
Abstract
  • "The insulin-like growth factors (IGF-I and IGF-II) are small polypeptides (Mr -7500) that control growth of multiple cell types. Cells derived from all three embryonic lineages contain IGF receptors, and almost all cell types have been shown to respond to IGFs (79). The IGFs stimulate multiple cellular responses that are related to growth, including synthesis of DNA, RNA, and cellular protein (80). IGF-I and IGF-II signal cells that adequate nutrient is available in the microenvironment for the cell to enter the ""s"" phase of the cell cycle (7 1). Experiments conducted in Balb/c 3T3 fibroblasts have shown that when nutrients are deficient (usually, essential amino acids), the addition of IGF-I is sufficient to overcome growth arrest in the fibroblasts (4 1). Support for the concept of nutrient-dependent growth signalling derives from the observation that the IGFs stimulate both amino acid transport (40) and protein synthesis (64) in skeletal tissues and have the potential to fulfill an important role as mediators of tissue anabolism."
Date of publication
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Identifier
  • doi:10.1146/annurev.nu.11.070191.002141
  • 2-s2.0-0025817718
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Resource type
  • Journal Item
Rights statement
  • In Copyright
Journal title
  • Annual Review of Nutrition
Journal volume
  • 11
Page start
  • 393
Page end
  • 412
Language
  • English
Version
  • Postprint
ISSN
  • 0199-9885
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