Seroprevalence of Human Papillomavirus Types 6, 11, 16 and 18 in Chinese Women Public Deposited

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Creator
  • Pretorius, Robert G
    • Other Affiliation: Department of Obstetrics and Gynecology, S.C.P.M.G.-Fontana, 9961 Sierra Ave, Fontana, CA, 92335, USA
  • Chen, Wen
    • Other Affiliation: Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan, Beijing 100021, China
  • Ji, Jia
    • Other Affiliation: Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan, Beijing 100021, China; Division of Pharmaceutics, College of Pharmacy, Ohio State University, 500 W 12th Ave, Columbus, OH, 43210, USA
  • Hu, Shangying
    • Other Affiliation: Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan, Beijing 100021, China
  • Esser, Mark T
    • Other Affiliation: Department of Vaccine Research, Merck Research Laboratories, Merck and Company Incorporated, 770 Sumneytown Pike, West Point, PA, 19486, USA; Present address: PPD Vaccines and Biologics Center of Excellence, 466 Devon Park Drive, Wayne, PA, 19087, USA
  • Belinson, Jerome L
    • Other Affiliation: Department of Obstetrics and Gynecology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
  • Qiao, You-Lin
    • Other Affiliation: Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan, Beijing 100021, China; Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences, 17 Panjiayuan, Beijing 100021, China
  • Smith, Jennifer S
    • Other Affiliation: Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan, Beijing 100021, China
  • Wang, He
    • Other Affiliation: Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan, Beijing 100021, China
  • Sun, Hai-Kui
    • Other Affiliation: Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan, Beijing 100021, China
Abstract
  • Abstract Background Human papillomavirus (HPV) seroprevalence data have not previously been reported for different geographical regions of China. This study investigated the cross-sectional seroprevalence of antibodies to HPV 6, 11, 16, and 18 virus-like particles in Chinese women. Methods Population-based samples of women were enrolled from 2006 to 2007 in 3 rural and 2 urban areas of China. Each consenting woman completed a questionnaire and provided a blood sample. Serum antibodies were detected using a competitive Luminex immunoassay that measures antibodies to type-specific, neutralizing epitopes on the virus-like particles. Results A total of 4,731 women (median age 35, age range 14-54) were included, of which 4,211 were sexually active women (median age 37) and 520 virgins (median age 18). Low risk HPV 6 was the most common serotype detected (7.3%), followed by HPV 16 (5.6%), HPV 11 (2.9%), and HPV 18 (1.9%). Overall HPV seroprevalence to any type was significantly higher among sexually active women (15.8%) than virgins (2.5%) (P = 0.005). Overall seroprevalence among sexually active women gradually increased with age. Women from rural regions had significantly lower overall seroprevalence (Odds Ratio (OR) = 0.7; 95% CI: 0.6-0.9, versus metropolitan regions, P < 0.001). With increasing number of sexual partners, women were at higher risk of seropositivity of any type (OR = 2.6; 95% CI: 1.7-3.9 for > = 4 partners versus 1 partner, P < 0.001). Wives were at higher risk of seropositivity for HPV 16/18/6/11 when reporting having a husband who had an extramarital sexual relationship (OR = 2.0; 95% CI: 1.6-2.5, versus those whose husbands having no such relationship, P < 0.001). There was a strong association between HPV 16 seropositivity and presence of high-grade cervical lesions (OR = 6.5; 95% CI: 3.7-11.4, versus normal cervix, P < 0.001). Conclusions HPV seroprevalence differed significantly by age, geography, and sexual behavior within China, which all should be considered when implementing an optimal prophylactic HPV vaccination program in China.
Date of publication
Identifier
  • doi:10.1186/1471-2334-12-137
  • 22715915
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • Jia Ji et al.; licensee BioMed Central Ltd.
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Journal title
  • BMC Infectious Diseases
Journal volume
  • 12
Journal issue
  • 1
Page start
  • 137
Language
  • English
Is the article or chapter peer-reviewed?
  • Yes
ISSN
  • 1471-2334
Bibliographic citation
  • BMC Infectious Diseases. 2012 Jun 20;12(1):137
Access
  • Open Access
Publisher
  • BioMed Central Ltd
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