Effect of SARS-CoV-2 Infection and Infection Severity on Longer-Term Glycemic Control and Weight in People With Type 2 Diabetes

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  • Wong, R.
    • Other Affiliation: Stony Brook University
  • Vaddavalli, R.
    • Other Affiliation: Stony Brook University
  • Hall, M.A.
    • Other Affiliation: Stony Brook University
  • Patel, M.V.
    • Other Affiliation: Stony Brook University
  • Bramante, C.T.
    • Other Affiliation: University of Minnesota Medical School
  • Casarighi, E.
    • Other Affiliation: Universita degli Studi di Milano
  • Johnson, S.G.
    • Other Affiliation: University of Minnesota
  • Lingam, V.
    • Other Affiliation: Stony Brook University
  • Miller, J.D.
    • Other Affiliation: Stony Brook University
  • Reusch, J.
    • Other Affiliation: University of Colorado Anschutz Medical Campus
  • Saltz, M.
    • Other Affiliation: Stony Brook University
  • Sturmer, T.
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology
  • Tronieri, J.S.
    • Other Affiliation: University of Pennsylvania
  • Wilkins, K.J.
    • Other Affiliation: National Institutes of Health
  • Buse, J.B.
    • Affiliation: School of Medicine, Department of Medicine
  • Saltz, J.
    • Other Affiliation: Stony Brook University
  • Huling, J.D.
    • Other Affiliation: University of Minnesota
  • Moffitt, R.
    • Other Affiliation: Stony Brook University
  • N3C Consortium
Abstract
  • OBJECTIVE To evaluate the association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severity of infection with longer-term glycemic control and weight in people with type 2 diabetes (T2D) in the U.S. RESEARCH DESIGN AND METHODS We conducted a retrospective cohort study using longitudinal electronic health record data of patients with SARS-CoV-2 infection from the National COVID Cohort Collaborative (N3C). Patients were ‡18 years old with an ICD-10 diagnosis of T2D and at least one HbA1c and weight measurement prior to and after an index date of their first coronavirus disease 2019 (COVID-19) diagnosis or negative SARS-CoV-2 test. We used propensity scores to identify a matched cohort bal-anced on demographic characteristics, comorbidities, and medications used to treat diabetes. The primary outcome was the postindex average HbA1c and post-index average weight over a 1 year time period beginning 90 days after the index date among patients who did and did not have SARS-CoV-2 infection. Secondary outcomes were postindex average HbA1c and weight in patients who required hospitalization or mechanical ventilation. RESULTS There was no significant difference in the postindex average HbA1c or weight in patients who had SARS-CoV-2 infection compared with control subjects. Mechanical ventilation was associated with a decrease in average HbA1c after COVID-19. CONCLUSIONS In a multicenter cohort of patients in the U.S. with preexisting T2D, there was no significant change in longer-term average HbA1c or weight among patients who had COVID-19. Mechanical ventilation was associated with a decrease in HbA1c after COVID-19.
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Resource type
  • Article
Rights statement
  • In Copyright
Journal title
  • Diabetes Care
Journal volume
  • 45
Journal issue
  • 11
Page start
  • 2709
Page end
  • 2717
Language
  • English
Funder
  • Foundation for the National Institutes of Health, FNIH: P30DK124723, R01 AG056479
  • National Institutes of Health, NIH
  • K23DK116935, UL1TR002489
  • National Center for Advancing Translational Sciences, NCATS: U24 TR002306
  • National Institute on Aging, NIA: R01 HL118255, R01 MD011680
  • Novo Nordisk
ISSN
  • 0149-5992
Publisher
  • American Diabetes Association Inc.

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