Global Assessment of Dengue Virus-Specific CD4+ T Cell Responses in Dengue-Endemic Areas

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Creator
  • Grifoni, Alba
    • Other Affiliation: Division of Vaccine Discovery; La Jolla Institute for Allergy and Immunology
  • Angelo, Michael A.
    • Other Affiliation: Division of Vaccine Discovery; La Jolla Institute for Allergy and Immunology
  • Lopez, Benjamin
    • Other Affiliation: Division of Vaccine Discovery; La Jolla Institute for Allergy and Immunology
  • O'Rourke, Patrick H.
    • Other Affiliation: Division of Vaccine Discovery; La Jolla Institute for Allergy and Immunology
  • Sidney, John
    • Other Affiliation: Division of Vaccine Discovery; La Jolla Institute for Allergy and Immunology
  • Cerpas, Cristhiam
    • Other Affiliation: Laboratorio Nacional de Virología; Centro Nacional de Diagnóstico y Referencia; Ministerio de Salud
  • Balmaseda, Angel
    • Other Affiliation: Laboratorio Nacional de Virología; Centro Nacional de Diagnóstico y Referencia; Ministerio de Salud
  • Silveira, Cassia G.T.
    • Other Affiliation: Division of Clinical Immunology and Allergy; School of Medicine; University of São Paulo
  • Maestri, Alvino
    • Other Affiliation: Division of Clinical Immunology and Allergy; School of Medicine; University of São Paulo
  • Costa, Priscilla R.
    • Other Affiliation: Division of Clinical Immunology and Allergy; School of Medicine; University of São Paulo
  • Durbin, Anna P.
    • Other Affiliation: Johns Hopkins University Bloomberg School of Public Health
  • Diehl, Sean A.
    • Other Affiliation: Vaccine Testing Center; Department of Medicine; Larner College of Medicine; University of Vermont
  • Phillips, Elizabeth
    • Other Affiliation: Institute for Immunology and Infectious Diseases; Murdoch University
  • Mallal, Simon
    • Other Affiliation: Institute for Immunology and Infectious Diseases; Murdoch University
  • de Silva, Aruna D.
    • Other Affiliation: Genetech Research Institute
  • Nchinda, Godwin
    • Other Affiliation: Chantal BIYA International Reference Centre for Research on the Prevention and Management of HIV/AIDS CIRCB
  • Nkenfou, Celine
    • Other Affiliation: Chantal BIYA International Reference Centre for Research on the Prevention and Management of HIV/AIDS CIRCB
  • Collins, Matthew H.
    • Affiliation: School of Medicine, Department of Microbiology and Immunology
  • de Silva, Aravinda M.
    • Affiliation: School of Medicine, Department of Microbiology and Immunology
    • Other Affiliation: Faculty of Medicine; Department of Paraclinical Sciences; Kotelawala Defense University
  • Lim, Mei Qiu
    • Other Affiliation: Emerging Infectious Disease Programme; Duke-NUS Medical School
  • Macary, Paul A.
    • Other Affiliation: Immunology Programme; Department of Microbiology and Immunology; Life Sciences Institute; National University of Singapore
  • Tatullo, Filippo
    • Other Affiliation: Institute of Infection and Global Health; University of Liverpool
  • Solomon, Tom
    • Other Affiliation: Institute of Infection and Global Health; University of Liverpool
  • Satchidanandam, Vijaya
    • Other Affiliation: Department of Microbiology and Cell Biology; Indian Institute of Science
  • Desai, Anita
    • Other Affiliation: Neurovirology; National Institute of Mental Health and Neurosciences (NIMHANS)
  • Ravi, Vasanthapram
    • Other Affiliation: Neurovirology; National Institute of Mental Health and Neurosciences (NIMHANS)
  • Coloma, Josefina
    • Other Affiliation: Division of Infectious Diseases and Vaccinology; School of Public Health; University of California
  • Turtle, Lance
    • Other Affiliation: Institute of Infection and Global Health; University of Liverpool
  • Rivino, Laura
    • Other Affiliation: Emerging Infectious Disease Programme; Duke-NUS Medical School
  • Kallas, Esper G.
    • Other Affiliation: Division of Clinical Immunology and Allergy; School of Medicine; University of São Paulo
  • Peters, Bjoern
    • Other Affiliation: Division of Vaccine Discovery; La Jolla Institute for Allergy and Immunology
  • Harris, Eva
    • Other Affiliation: Division of Infectious Diseases and Vaccinology; School of Public Health; University of California
  • Sette, Alessandro
    • Other Affiliation: Division of Vaccine Discovery; La Jolla Institute for Allergy and Immunology
  • Weiskopf, Daniela
    • Other Affiliation: Division of Vaccine Discovery; La Jolla Institute for Allergy and Immunology
Abstract
  • Dengue is a major public health problem worldwide. Assessment of adaptive immunity is important to understanding immunopathology and to define correlates of protection against dengue virus (DENV). To enable global assessment of CD4+ T cell responses, we mapped HLA-DRB1-restricted DENV-specific CD4+ T cell epitopes in individuals previously exposed to DENV in the general population of the dengue-endemic region of Managua, Nicaragua.
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Resource type
  • Article
Rights statement
  • In Copyright
Journal title
  • Frontiers in Immunology
Journal volume
  • 8
Language
  • English
ISSN
  • 1664-3224

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