Maternal exercise before and during pregnancy does not impact offspring exercise or body composition in mice Public Deposited

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Creator
  • Kelly, Scott A
    • Other Affiliation: Department of Zoology, Ohio Wesleyan University, Delaware, USA
  • Wallace, Jennifer N
    • Other Affiliation: Department of Zoology, Ohio Wesleyan University, Delaware, USA
  • Pomp, Daniel
    • Affiliation: School of Medicine, Department of Genetics
  • Hua, Kunjie
    • Affiliation: School of Medicine, Department of Genetics
  • Nehrenberg, Derrick L
    • Affiliation: School of Medicine, Department of Genetics
  • Wells, Sarah E
    • Other Affiliation: Department of Zoology, Ohio Wesleyan University, Delaware, USA
Abstract
  • Abstract Background The genome, the environment, and their interactions simultaneously regulate complex traits such as body composition and voluntary exercise levels. One such environmental influence is the maternal milieu (i.e., in utero environment or maternal care). Variability in the maternal environment may directly impact the mother, and simultaneously has the potential to influence the physiology and/or behavior of offspring in utero, post birth, and into adulthood. Here, we utilized a murine model to examine the effects of the maternal environment in regard to voluntary exercise (absence of wheel running, wheel running prior to gestation, and wheel running prior to and throughout gestation) on offspring weight and body composition (% fat tissue and % lean tissue) throughout development (~3 to ~9 weeks of age). Additionally, we examined the effects of ~6 weeks of maternal exercise (prior to and during gestation) on offspring exercise levels at ~9 weeks of age. Results We observed no substantial effects of maternal exercise on subsequent male or female offspring body composition throughout development, or on the propensity of offspring to engage in voluntary wheel running. At the level of the individual, correlational analyses revealed some statistically significant relationships between maternal and offspring exercise levels, likely reflecting previously known heritability estimates for such traits. Conclusions The current results conflict with previous findings in human and mouse models demonstrating that maternal exercise has the potential to alter offspring phenotypes. We discuss our negative findings in the context of the timing of the maternal exercise and the level of biological organization of the examined phenotypes within the offspring.
Date of publication
Identifier
  • doi:10.1186/s12952-015-0032-x
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • Kelly et al.
Language
  • English
Bibliographic citation
  • Journal of Negative Results in BioMedicine. 2015 Aug 03;14(1):13
Publisher
  • BioMed Central
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