Effect of innate antiviral glycoproteins in breast milk on seroconversion to rotavirus vaccine (Rotarix) in children in Lusaka, Zambia

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Mwila-Kazimbaya, Katayi
- Other Affiliation: Department of biomedical sciences; School of Health sciences; University of Zambia
Garcia, Miguel Pugliese
- Other Affiliation: Centre for Infectious Disease Research in Zambia
Bosomprah, Samuel
- Other Affiliation: Department of Biostatistics; School ofPublic Health; University of Ghana
Laban, Natasha Makabilo
- Other Affiliation: Centre for Infectious Disease Research in Zambia
Chisenga, Caroline Cleopatra
- Other Affiliation: Centre for Infectious Disease Research in Zambia
Permar, Sallie Robey
- Other Affiliation: Department of Paediatrics; Human VaccineInstitute; Duke University
Simuyandi, Michelo
- Other Affiliation: Centre for Infectious Disease Research in Zambia
Munsaka, Sody
- Other Affiliation: Department of biomedical sciences; School of Health sciences; University of Zambia
Chilengi, Roma
- Affiliation: School of Medicine
- Other Affiliation: Centre for Infectious Disease Research in Zambia

Abstract

Rotavirus vaccines have been introduced into national immunization programmes to mitigate morbidity and mortality associated rotavirus diarrhoea. Lower vaccine effectiveness has however been noted in low-middle income countries, but little is known about the role of maternal components found in breast milk. This study assessed the effect of lactoferrin, lactadherin, and tenascin-c on rotavirus vaccine seroconversion.

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