Chronic Opisthorchis viverrini Infection and Associated Hepatobiliary Disease Is Associated with Iron Loaded M2-like Macrophages
Public Deposited- Creator
- Bility, Moses T.
- Sripa, Banchob
- Abstract
- Chronic Opisthorchis viverrini-induced hepatobiliary disease is associated with significant leukocyte infiltration, including activated macrophages; however, the polarization of infiltrating macrophages remains to be fully characterized. In this study, we characterized macrophage polarization and phenotype in chronic O. viverrini-induced hepatobiliary disease in humans and hamsters using gene expression and histochemical analysis. Chronic O. viverrini infection and associated hepatobiliary diseases were associated with iron loaded M2-like macrophages in both humans and hamsters. This study provides suggestive evidence that iron loaded M2-like macrophages promote hepatobiliary disease in chronic O. viverrini infection.
- Date of publication
- 2014
- Keyword
- DOI
- Identifier
- Publisher DOI: https://doi.org/10.3347/kjp.2014.52.6.695
- Onescience id: dc4e3d36edf4b28388c033ed309029d173ff608e
- PMCID: PMC4277036
- PMID: 25548425
- Resource type
- Article
- Rights statement
- In Copyright
- Journal title
- The Korean Journal of Parasitology
- Journal volume
- 52
- Journal issue
- 6
- Page start
- 695
- Page end
- 699
- Language
- English
- ISSN
- 0023-4001
- 1738-0006
Relations
- Parents:
This work has no parents.
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