A Functional Assessment Tool to Distinguish Controls From Alzheimer’s Disease in Lima, Peru

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Creator
  • Custodio, N.
    • Other Affiliation: Instituto Peruano de Neurociencias
  • Montesinos, R.
    • Other Affiliation: Instituto Peruano de Neurociencias
  • Chambergo-Michilot, D.
    • Other Affiliation: Universidad Científica Del Sur
  • Herrera-Perez, E.
    • Other Affiliation: Instituto Peruano de Neurociencias
  • Pintado-Caipa, M.
    • Other Affiliation: Instituto Peruano de Neurociencias
  • Seminario G, W.
    • Other Affiliation: Instituto Peruano de Neurociencias
  • Cuenca, J.
    • Other Affiliation: Instituto Peruano de Neurociencias
  • Mesía, L.
    • Other Affiliation: Instituto Peruano de Neurociencias
  • Failoc-Rojas, V.E.
    • Other Affiliation: Instituto Peruano de Neurociencias
  • Diaz, M.M.
    • Affiliation: School of Medicine, Department of Neurology
Abstract
  • Background The Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) scale is a versatile functional assessment tool for patients with Alzheimer's disease (AD). We evaluated its performance in controls, Peruvians with MCI or AD. Methods A cross-sectional study of older adults attending a neurology institute in Lima (Peru) with mild cognitive impairment (MCI), ad or cognitively healthy. Test-retest reliability (intraclass correlation coefficient, ICC; internal consistency, Cronbach's alpha) and validity were assessed. Results We enrolled 276 individuals (AD: 113, MCI: 68, controls: 95) with no age, sex, educational level, and depressive symptom differences. Reliability was ideal (ICC: .996), and Cronbach's alpha was adequate (.937). The ADCS-ADL could not differentiate MCI from controls but did differentiate AD severity. The ADCS-ADL correlated highly with nearly all tools. Conclusions The ADCS-ADL scale is reliable in a population with AD in Lima, Peru. Future work may validate a tool for Peruvians with lower educational levels.
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  • Article
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  • In Copyright
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  • Attribution 4.0 International
Journal title
  • American Journal of Alzheimer's Disease & Other Dementias®
Journal volume
  • 37
Language
  • English
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  • Publisher
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  • National Institute on Aging, NIA: 1R56AG069118-01, 5P30AG059299
ISSN
  • 1533-3175
Publisher
  • SAGE Publications Ltd

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