Immunogenicity of rotavirus vaccine (RotarixTM) in infants with environmental enteric dysfunction

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Mwape, Innocent
- Other Affiliation: Center for Infectious Disease Research in Zambia
Bosomprah, Samuel
- Other Affiliation: Center for Infectious Disease Research in Zambia
Mwaba, John
- Other Affiliation: Center for Infectious Disease Research in Zambia
Mwila-Kazimbaya, Katayi
- Other Affiliation: Center for Infectious Disease Research in Zambia
Laban, Natasha Makabilo
- Other Affiliation: Center for Infectious Disease Research in Zambia
Chisenga, Caroline Cleopatra
- Other Affiliation: Center for Infectious Disease Research in Zambia
Sijumbila, Gibson
- Other Affiliation: Department of Physiologicalsciences; University of Zambia
Simuyandi, Michelo
- Other Affiliation: Center for Infectious Disease Research in Zambia
Chilengi, Roma
- Affiliation: University of North Carolina at Chapel Hill
- Other Affiliation: Center for Infectious Disease Research in Zambia

Abstract

Deployment of rotavirus vaccines has contributed to significant declines in diarrheal morbidity and mortality globally. Unfortunately, vaccine performance in low-middle income countries (LMICs) is generally lower than in developed countries. The cause for this has been associated with several host and maternal factors including poor water sanitation and hygiene (WASH) status, which are predominant in LMICs. More recently, environmental enteric dysfunction (EED) has specifically been hypothesized to contribute to poor vaccine uptake and response. The aim of this study was to examine the association between serological biomarkers of EED and seroconversion to rotavirus vaccine in Zambian infants.

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