Target weight achievement and ultrafiltration rate thresholds: potential patient implications Public Deposited

Downloadable Content

Download PDF
  • Assimon, Magdalene M
    • Affiliation: Gillings School of Global Public Health, Department of Epidemiology, School of Medicine, Department of Medicine, Division of Nephrology and Hypertension, UNC Kidney Center
  • Flythe, Jennifer
    • Affiliation: Cecil G. Sheps Center for Health Services Research, School of Medicine, Department of Medicine, Division of Nephrology and Hypertension, UNC Kidney Center
  • Overman, Robert A
    • Affiliation: Eshelman School of Pharmacy, School of Medicine, Department of Medicine, Division of Nephrology and Hypertension, UNC Kidney Center, Division of Pharmaceutical Outcomes and Policy
  • Abstract Background Higher ultrafiltration (UF) rates and extracellular hypo- and hypervolemia are associated with adverse outcomes among maintenance hemodialysis patients. The Centers for Medicare and Medicaid Services recently considered UF rate and target weight achievement measures for ESRD Quality Incentive Program inclusion. The dual measures were intended to promote balance between too aggressive and too conservative fluid removal. The National Quality Forum endorsed the UF rate measure but not the target weight measure. We examined the proposed target weight measure and quantified weight gains if UF rate thresholds were applied without treatment time (TT) extension or interdialytic weight gain (IDWG) reduction. Methods Data were taken from the 2012 database of a large dialysis organization. Analyses considered 152,196 United States hemodialysis patients. We described monthly patient and dialysis facility target weight achievement patterns and examined differences in patient characteristics across target weight achievement status and differences in facilities across target weight measure scores. We computed the cumulative, theoretical 1-month fluid-related weight gain that would occur if UF rates were capped at 13 mL/h/kg without concurrent TT extension or IDWG reduction. Results Target weight achievement patterns were stable over the year. Patients who did not achieve target weight (post-dialysis weight ≥ 1 kg above or below target weight) tended to be younger, black and dialyze via catheter, and had shorter dialysis vintage, greater body weight, higher UF rate and more missed treatments compared with patients who achieved target weight. Facilities had, on average, 27.1 ± 9.7% of patients with average post-dialysis weight ≥ 1 kg above or below the prescribed target weight. In adjusted analyses, facilities located in the midwest and south and facilities with higher proportions of black and Hispanic patients and higher proportions of patients with shorter TTs were more likely to have unfavorable facility target weight measure scores. Without TT extension or IDWG reduction, UF rate threshold (13 mL/h/kg) implementation led to an average theoretical 1-month, fluid-related weight gain of 1.4 ± 3.0 kg. Conclusions Target weight achievement patterns vary across clinical subgroups. Implementation of a maximum UF rate threshold without adequate attention to extracellular volume status may lead to fluid-related weight gain.
Date of publication
  • doi:10.1186/s12882-017-0595-5
Resource type
  • Article
Rights statement
  • In Copyright
Rights holder
  • The Author(s).
  • English
Bibliographic citation
  • BMC Nephrology. 2017 Jun 02;18(1):185
  • BioMed Central

This work has no parents.