The Use of Functional Data Analysis to Evaluate Activity in a Spontaneous Model of Degenerative Joint Disease Associated Pain in Cats

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  • Gruen, Margaret E.
    • Other Affiliation: Comparative Medicine Institute; North Carolina State University
  • Alfaro-Córdoba, Marcela
    • Other Affiliation: Department of Statistics; North Carolina State University
  • Thomson, Andrea E.
    • Other Affiliation: Comparative Pain Research Program; Department of Clinical Sciences; College of Veterinary Medicine; North Carolina State University
  • Worth, Alicia C.
    • Other Affiliation: Comparative Pain Research Program; Department of Clinical Sciences; College of Veterinary Medicine; North Carolina State University
  • Staicu, Ana-Maria
    • Other Affiliation: Department of Statistics; North Carolina State University
  • Lascelles, B. Duncan X.
    • Affiliation: School of Dentistry, Center for Pain Research and Innovation
    • Other Affiliation: Comparative Medicine Institute; North Carolina State University
Abstract
  • Accelerometry is used as an objective measure of physical activity in humans and veterinary species. In cats, one important use of accelerometry is in the study of therapeutics designed to treat degenerative joint disease (DJD) associated pain, where it serves as the most widely applied objective outcome measure. These analyses have commonly used summary measures, calculating the mean activity per-minute over days and comparing between treatment periods. While this technique has been effective, information about the pattern of activity in cats is lost. In this study, functional data analysis was applied to activity data from client-owned cats with (n = 83) and without (n = 15) DJD. Functional data analysis retains information about the pattern of activity over the 24-hour day, providing insight into activity over time. We hypothesized that 1) cats without DJD would have higher activity counts and intensity of activity than cats with DJD; 2) that activity counts and intensity of activity in cats with DJD would be inversely correlated with total radiographic DJD burden and total orthopedic pain score; and 3) that activity counts and intensity would have a different pattern on weekends versus weekdays.
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  • Article
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  • In Copyright
Journal title
  • PloS One
Journal volume
  • 12
Journal issue
  • 1
Page start
  • e0169576
Language
  • English
ISSN
  • 1932-6203

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